Characterization of an arabinogalactan from the fruit hulls of Ficus pumila Linn. and its immunomodulatory effect
| Autor: | Luping Qin, Yunjie Sheng, Jianjun Wu, Qiao-Yan Zhang, Shunchun Wang, Songshan Shi, Bo Zhu, Yongbin Xu, Huijun Wang, Siqi Wang, Kao-Hua Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Ficus pumila Linn. fruit hulls 030109 nutrition & dietetics Nutrition and Dietetics Immunomodulatory effect biology Traditional medicine Arabinogalactan Physicochemical properties Nutrition. Foods and food supply Medicine (miscellaneous) 04 agricultural and veterinary sciences biology.organism_classification 040401 food science Ficus pumila 03 medical and health sciences 0404 agricultural biotechnology Functional food TX341-641 Immunomodulatory Agent History of use No production Food Science |
| Zdroj: | Journal of Functional Foods, Vol 73, Iss, Pp 104091-(2020) |
| ISSN: | 1756-4646 |
| Popis: | Ficus pumila Linn. fruits has a long history of use as a functional food in East Asia. The present study developed a consecutive process for the production of an arabinogalactan (FPW) from the fruit hulls of Ficus pumila Linn.. FPW was identified as a type II arabinogalactan with a 1,3-β-D-Galp backbone with O-6 branching to 1,6-linked Gal side chains or terminal-β-D-Galp, and has a molecular weight of 156 kDa. FPW was proved be capable of promoting NO production, phagocytic activity, and the secretion of cytokines including TNF-α, IL-1β and IL-6 without inducing substantial cytotoxicity on RAW 264.7 cells, suggesting the potential utilization of FPW as an immunomodulatory agent. The obtained results emphasize Ficus pumila L. fruit hulls as a potentially ideal source of viable and naturally-derived immunomodulatory materials, also providing a method for obtaining the active arabinogalactan from Ficus pumila L. fruit hulls. |
| Databáze: | OpenAIRE |
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