Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation
| Autor: | Jan H. Jensen, Maria Dons, Daniel Modin, Flemming Javier Olsen, Tor Biering-Sørensen, Thomas Fritz-Hansen, Peter Godsk Jørgensen, Niels Eske Bruun, Morten Sengeløv |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Global longitudinal strain
Male Longitudinal strain Denmark RR interval Heart Ventricles/diagnostic imaging Ventricular Function Left Electrocardiography Original Research Articles Cause of Death Atrial Fibrillation Original Research Article Survival Rate/trends Atrial fibrillation Heart failure with reduced ejection fraction Prognosis Survival Rate Echocardiography Cardiology Female Cardiology and Cardiovascular Medicine Atrial Fibrillation/complications Heart Failure Systolic/complications medicine.medical_specialty Heart Ventricles Cause of Death/trends Risk Assessment Internal medicine medicine Journal Article Humans In patient Risk stratification Speckle tracking Retrospective Studies Aged Myocardial Contraction/physiology business.industry Stroke Volume medicine.disease Myocardial Contraction Denmark/epidemiology Stroke Volume/physiology Heart failure business All cause mortality Heart Failure Systolic Follow-Up Studies |
| Zdroj: | Modin, D, Sengeløv, M, Jørgensen, P G, Bruun, N E, Olsen, F J, Dons, M, Fritz Hansen, T, Jensen, J S & Biering-Sørensen, T 2018, ' Global longitudinal strain corrected by RR interval is a superior predictor of all-cause mortality in patients with systolic heart failure and atrial fibrillation ', E S C Heart Failure, vol. 5, no. 2, pp. 311-318 . https://doi.org/10.1002/ehf2.12220 ESC Heart Failure |
| DOI: | 10.1002/ehf2.12220 |
| Popis: | AIMS: Quantification of systolic function in patients with atrial fibrillation (AF) is challenging. A novel approach, based on RR interval correction, to counteract the varying heart cycle lengths in AF has recently been proposed. Whether this method is superior in patients with systolic heart failure (HFrEF) with AF remains unknown. This study investigates the prognostic value of RR interval-corrected peak global longitudinal strain {GLSc = GLS/[RR^(1/2)]} in relation to all-cause mortality in HFrEF patients displaying AF during echocardiographic examination.METHODS AND RESULTS: Echocardiograms from 151 patients with HFrEF and AF during examination were analysed offline. Peak global longitudinal strain (GLS) was averaged from 18 myocardial segments obtained from three apical views. GLS was indexed with the square root of the RR interval {GLSc = GLS/[RR^(1/2)]}. Endpoint was all-cause mortality. During a median follow-up of 2.7 years, 40 patients (26.5%) died. Neither uncorrected GLS (P = 0.056) nor left ventricular ejection fraction (P = 0.053) was significantly associated with all-cause mortality. After RR^(1/2) indexation, GLSc became a significant predictor of all-cause mortality (hazard ratio 1.16, 95% confidence interval 1.02-1.22, P = 0.014, per %/s^(1/2) decrease). GLSc remained an independent predictor of mortality after multivariable adjustment (age, sex, mean heart rate, mean arterial blood pressure, left atrial volume index, and E/e') (hazard ratio 1.17, 95% confidence interval 1.05-1.31, P = 0.005 per %/s^(1/2) decrease).CONCLUSIONS: Decreasing {GLSc = GLS/[RR^(1/2)]}, but not uncorrected GLS nor left ventricular ejection fraction, was significantly associated with increased risk of all-cause mortality in HFrEF patients with AF and remained an independent predictor after multivariable adjustment. |
| Databáze: | OpenAIRE |
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