Prognostic value of key genes of the JAK‑STAT signaling pathway in patients with cutaneous melanoma
| Autor: | Haiyan Mo, Fuqiang Pan, Qiaoqi Wang, Xiang Zhou, Sizhu Li, Xiwen Liao, Liming Zhang, Rui Huang, Xiangkun Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Janus kinase-signal transducer and activator of transcription signaling pathway
Cancer Research Oncogene biology business.industry Melanoma JAK-STAT signaling pathway STAT5B Articles medicine.disease Oncology melanoma Cancer research biology.protein Medicine prognosis STAT1 business STAT4 Survival analysis STAT6 |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway is involved in cell immunity, division and death, as well as in tumor formation. The expression of key genes in the JAK-STAT signaling pathway in different types of cancer serves different roles. However, few reports are available on the prognostic value of the genes of the JAK-STAT signaling pathway in skin cutaneous melanoma (SKCM). The potential prognostic value of gene expression in the JAK-STAT signaling pathway in patients with SKCM was analyzed in the present study using data obtained from The Cancer Genome Atlas. To predict the potential functions and mechanisms of these genes in SKCM, gene set enrichment analysis (GSEA) and bioinformatics analysis were performed. A nomogram model including gene expression level and high risk factors was used to predict the risk level of prognostic. High expression levels of STAT1, STAT3, STAT4 and STAT5B, and low expression levels of STAT6 were associated with favorable prognosis [adjusted P |
| Databáze: | OpenAIRE |
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