A novel automated discontinuous venous blood monitoring system for ex vivo glucose determination in humans
| Autor: | Thomas R. Pieber, Hans Köhler, R. Hainisch, Johannes Plank, Lukas Schaupp, M. Ellmerer, Roland Schaller, Franz Feichtner, Manfred Bodenlenz, Andrea Wutte, H. Wedig, Julia K. Mader, R. Hellmich |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
medicine.medical_treatment Biomedical Engineering Biophysics Biosensing Techniques Sensitivity and Specificity Catheterization Phlebotomy Electrochemistry medicine Humans Vein business.industry Critically ill Insulin Reproducibility of Results Sampling (statistics) Monitoring system Equipment Design Robotics General Medicine Venous blood Equipment Failure Analysis medicine.anatomical_structure Anesthesia Flow Injection Analysis business Blood Chemical Analysis Ex vivo Biotechnology Blood sampling |
| Zdroj: | Biosensors and Bioelectronics. 24:2239-2245 |
| ISSN: | 0956-5663 |
| Popis: | Intensive insulin therapy reduces mortality and morbidity in critically ill patients but imposes great demands on medical staff who must take frequent blood samples for the determination of glucose levels. A solution to this resourcing problem would be provided by an automated blood monitoring system. The aim of the present clinical study was to evaluate such a system comprising an automatic blood sampling unit linked to a glucose biosensor. Our approach was to determine the correlation and system error of the sampling unit alone and of the combined system with respect to reference levels over 12h in humans. Two venous cannulae were inserted to connect the automatic and reference systems to the subjects. Blood samples were taken at 15 and 30 min intervals. The median Pearson coefficient of correlation between manually and automatically withdrawn blood samples was 0.982 for the sampling unit alone and 0.950 for the complete system. The biosensor had a linear range up to 20 mmoll(-1) and a 95% response time of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect