Inhibition of benzo[a]pyrene-induced mutagenesis in Chinese hamster V79 cells by hemin and related compounds
| Autor: | Nobuo Nemoto, Yoichi Katoh, Machiko Tanaka, Shozo Takayama |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Cell Survival
Hamster Heme Chinese hamster Ouabain Cell Line Structure-Activity Relationship chemistry.chemical_compound Cricetulus Cricetinae Benzo(a)pyrene polycyclic compounds medicine Animals Benzopyrenes Mutation frequency Lung biology Mutagenicity Tests Chlorophyllin General Medicine respiratory system biology.organism_classification chemistry Biochemistry Mutation Hemin Protoporphyrin Drug Antagonism Mutagens medicine.drug |
| Zdroj: | Mutation Research Letters. 121:153-157 |
| ISSN: | 0165-7992 |
| DOI: | 10.1016/0165-7992(83)90114-8 |
| Popis: | The inhibitory effects of hemin and related compounds on the mutagenicity of benzo[a]pyrene (BP) were investigated in Chinese hamster V79 cells co-cultivated with X-irradiated hamster embryo cells. Mutant V79 cells were selected by their resistance to ouabain. The mutation frequency induced by BP was substantially inhibited dose dependently by hemin. The mutagenicity of BP (1 microgram/ml) on V79 cells was reduced to 6.5% by hemin, 52% by biliverdin, 73% by protoporphyrin and 85% by chlorophyllin at the highest concentration of the compounds tested (15 microM). |
| Databáze: | OpenAIRE |
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