Supplementary methods and Figures from The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

Autor: Andrew J. Steele, Jan A. Burger, Greg P. Coffey, Francesco Forconi, Graham Packham, Freda K. Stevenson, Jonathan C. Strefford, Anjali Pandey, Pamela B. Conley, Peter W.M. Johnson, Andrew Davies, Lindsay D. Smith, Jack Parnell, Alice Hayman, Sarah Wilmore, Marta Larrayoz, Rachel C. Dobson, Stefan Koehrer, Matthew D. Blunt
Rok vydání: 2023
Popis: Supplementary methods and Figures Supplementary Figure 1. Effect of cerdulatinib on Immobilised anti-IgM mediated signaling Supplementary Figure 2. Effect of cerdulatinib on soluble anti-IgM mediated signaling Supplementary Figure 3. Effect of cerdulatinib on Immobilised anti-IgD mediated signaling Supplementary Figure 4. Effect of cerdulatinib on soluble anti-IgD mediated signaling Supplementary Figure 5. Effect of cerdulatinib on anti-IgM induced calcium flux and IL-4 induced surface marker expression Supplementary Figure 6. Representative phosflow plots Supplementary Figure 7. Cerdulatinib overcomes the protective effect of BCR-stimulation and IL- 4/CD40L. Supplementary Figure 8. Mcl-1 and Bcl-XL but not Bcl-2 are downregulated by cerdulatinib Supplementary Figure 9. Effect of cerdulatinib on MCL-1 and BCL-XL mRNA expression
Databáze: OpenAIRE