Association between HbA1C (Glycated Hemoglobin) and Clinical Outcomes in Patients with Subarachnoid Hemorrhage After Neuro-intervention
| Autor: | Ho Jun Yi, Chan Woong Park, Jae Hoon Sung, Dong Hoon Lee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Subarachnoid hemorrhage Logistic regression Brain Ischemia Cellular and Molecular Neuroscience chemistry.chemical_compound Developmental Neuroscience Modified Rankin Scale Internal medicine medicine Humans Vasospasm Intracranial Stroke Aged Intracerebral hemorrhage Glycated Hemoglobin Receiver operating characteristic business.industry Vasospasm Middle Aged Subarachnoid Hemorrhage medicine.disease Prognosis Magnetic Resonance Imaging Treatment Outcome Neurology chemistry Female Glycated hemoglobin business Tomography X-Ray Computed |
| Zdroj: | Current neurovascular research. 18(1) |
| ISSN: | 1875-5739 |
| Popis: | Objective: Our study investigated the association between the level of HbA1c (glycated hemoglobin) at admission and the prognosis of aneurysmal subarachnoid hemorrhage (SAH). Methods: A total of 510 patients treated with neuro-intervention for aneurysmal SAH and with data for admission HbA1c (glycated hemoglobin) were included. Favorable clinical outcome was defined as modified Rankin Scale (mRS) score of 0-2 at 3 months. Receiver operating characteristic (ROC) curve analysis was used to identify the optimal cutoff value of HbA1C for unfavorable clinical outcomes. Logistic regression was used to evaluate the association between HbA1C level and outcomes. Results: The optimal cutoff value of HbA1C was identified as 6.0% (P < 0.001), and patients with a high HbA1C (≥ 6.0%) had a lower prevalence of favorable clinical outcomes than patients with low HbA1C (< 6.0%) (P < 0.001). High HbA1C (≥ 6.0%) was independently associated with unfavorable clinical outcome (OR 2.84; 95% CI: 1.52-5.44; P = 0.004). The risk of unfavorable clinical outcome was significantly increased in patients with HbA1C (≥ 7.0%, < 8%) and HbA1C (≥ 8.0%) compared with lower baseline HbA1C (≥ 6.0%, < 7%) values (OR 2.17; 95% CI: 1.87-5.13; P = 0.011 and OR 4.25; 95% CI: 3.17-8.41; P = 0.005). Conclusions: Our study showed that HbA1C could be an independent predictor of worse outcomes following neuro-intervention for aneurysmal SAH. High HbA1C (≥ 6.0%) was associated with unfavorable clinical outcomes, and gradual elevation of HbA1C contributed to an increase in the risk of worse clinical outcomes after SAH. |
| Databáze: | OpenAIRE |
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