Prognostic significance of MEOX2 in gliomas
| Autor: | Christos Petropoulos, Konstantin Masliantsev, Michel Wager, Julie Godet, Pierre Rivet, Lucie Karayan-Tapon, Serge Milin, Gaëlle Tachon, Pierre-Olivier Guichet |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Pathology IDH1 Mesenchyme Pathology and Forensic Medicine Young Adult 03 medical and health sciences 0302 clinical medicine Glioma Internal medicine Biomarkers Tumor medicine Humans Clinical significance Young adult Lung cancer neoplasms Transcription factor Aged Aged 80 and over Homeodomain Proteins Brain Neoplasms business.industry Middle Aged Prognosis medicine.disease nervous system diseases 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Homeobox Female business |
| Zdroj: | Modern Pathology. 32:774-786 |
| ISSN: | 0893-3952 |
| Popis: | Gliomas are the most common malignant primary tumors in the central nervous system and have variable predictive clinical courses. Glioblastoma, the most aggressive form of glioma, is a complex disease with unsatisfactory therapeutic solutions and a very poor prognosis. Some processes at stake in gliomagenesis have been discovered but little is known about the role of homeobox genes, even though they are highly expressed in gliomas, particularly in glioblastoma. Among them, the transcription factor Mesenchyme Homeobox 2 (MEOX2) had previously been associated with malignant progression and clinical prognosis in lung cancer and hepatocarcinoma but never studied in glioma. The aim of our study was to investigate the clinical significance of MEOX2 in gliomas. We assessed the expression of MEOX2 according to IDH1/2 molecular profile and patient survival among three different public datasets: The Cancer Genome Atlas (TCGA), The Chinese Glioma Genome Atlas (CGGA) and the US National Cancer Institute Repository for Molecular Brain Neoplasia Data (Rembrandt). We then evaluated the prognostic significance of MEOX2 protein expression on 112 glioma clinical samples including; 56 IDH1 wildtype glioblastomas, 7 IDH1 wild-type lower grade gliomas, 49 IDH1 mutated lower grade gliomas. Survival rates were estimated by the Kaplan-Meier method followed by uni/multivariate analyses. We demonstrated that MEOX2 was one of the transcription factors most closely associated with overall survival in glioma. Moreover, MEOX2 expression was associated with IDH1/2 wildtype molecular subtype and was significantly correlated with overall survival of all gliomas and, more interestingly, in lower grade glioma. To conclude, our results may be the first to provide insight into the clinical significance of MEOX2 in gliomas, which is a factor closely related to patient outcome. MEOX2 could constitute an interesting prognostic biomarker, especially for lower grade glioma. |
| Databáze: | OpenAIRE |
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