Anti-type I interferon antibodies as a cause of severe COVID-19
| Autor: | ADRIAN HAYDAY, Gregory Towers, Ivan Zanoni, David Fajgenbaum, Angela Rogers, Andreas Wack |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Aged 80 and over Male SARS-CoV-2 Critical Illness Pneumonia Viral COVID-19 Review Article Interferon alpha-2 Middle Aged Antibodies Neutralizing Betacoronavirus Case-Control Studies Immunoglobulin G Interferon Type I Humans Female Coronavirus Infections Asymptomatic Infections Pandemics Aged Autoantibodies |
| Zdroj: | Fac Rev |
| DOI: | 10.12703/r-01-0000010 |
| Popis: | Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|