Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective
| Autor: | Anna Lanzoni, Fernando Álvarez-Alfageme, Elisabeth Waigmann, Yann Devos, Nikoletta Papadopoulou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
DvSnf7 Mini Review dsRNA Plant Science Biology lcsh:Plant culture 01 natural sciences Off targets 03 medical and health sciences gene silencing RNA interference lcsh:SB1-1110 030304 developmental biology Environmental risk assessment International level 0303 health sciences business.industry genetically modified organisms fungi risk assessment Food safety crops Genetically modified organism Biotechnology RNAi business Risk assessment off-target 010606 plant biology & botany |
| Zdroj: | Frontiers in Plant Science, Vol 11 (2020) Frontiers in Plant Science |
| DOI: | 10.3389/fpls.2020.00445/full |
| Popis: | Genetically modified plants (GMPs) intended for market release can be designed to induce "gene silencing" through RNA interference (RNAi). The European Food Safety Authority (EFSA) and other international risk assessment bodies/regulatory agencies have taken several actions to determine whether the existing risk assessment approaches for GMPs are appropriate for the risk assessment of RNAi-based GMPs or require complementary or alternative approaches. To our knowledge, at the international level, no dedicated guidelines have been developed for the risk assessment and regulation of RNAi-based GMPs, confirming that existing science-based risk assessment approaches for GMPs are generally considered suitable for RNAi-based GMPs. However, some specificities have been identified for the risk assessment of RNAi-based GMPs. Here, we report on some of these specificities as identified and addressed by the EFSA GMO Panel for the molecular characterisation, food/feed safety assessment and environmental risk assessment of RNAi-based GMPs, using the DvSnf7 dsRNA-expressing maize MON87411 as a case study. |
| Databáze: | OpenAIRE |
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