Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight
| Autor: | Diane J. Berry, Bjarke Feenstra, Verena Sengpiel, Bo Jacobsson, Frank Geller, Ronny Myhre, Andrew P. Morris, Rachel M. Freathy, Timothy M. Frayling, Ville Huikari, Shikta Das, Bridget A. Knight, Eskil Kreiner-Møller, Penelope A. Lind, Lavinia Paternoster, Nicholas G. Martin, Marie-France Hivert, Jodie N. Painter, Janine F. Felix, Mads Melbye, Eco J. C. de Geus, Sylvain Sebert, Gonneke Willemsen, Susan M. Ring, Thorkild I. A. Sørensen, Janani Rangarajan, Debbie A Lawlor, Alana Cavadino, N. Maneka G. De Silva, Jessica Tyrrell, Luigi Bouchard, Mark I. McCarthy, Momoko Horikoshi, Denise M. Scholtens, Ellen A. Nohr, Jani Heikkinen, Sarah E. Medland, Vincent W. V. Jaddoe, Rebecca C Richmond, Hakon Hakonarson, Jouke-Jan Hottenga, Michael Nodzenski, Jonathan P. Bradfield, Loren L. Armstrong, M. Geoffrey Hayes, David M. Evans, Marjo-Riitta Järvelin, Catherine Allard, Struan F.A. Grant, George Davey Smith, Christine Power, Albert Hofman, George McMahon, Andrew T. Hattersley, Hans Bisgaard, Sarah Metrustry, Andrew R. Wood, Tom Palmer, Berthold Hocher, William L. Lowe, Christoph Reichetzeder, Elina Hyppönen, Jeff Murray, Tim D. Spector |
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| Přispěvatelé: | Erasmus MC other, Epidemiology, Pediatrics, Tyrrell, Jessica, Richmond, Rebecca C, Palmer, Tom M, Feenstra, Bjarke, Hypponen, Elina, Freathy, Rachel M, Early Growth Genetics (EGG) Consortium, Biological Psychology, EMGO+ - Lifestyle, Overweight and Diabetes |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Physiology BLOOD-PRESSURE Blood Pressure VITAMIN-D STATUS Type 2 diabetes Overweight Body Mass Index 0302 clinical medicine Pregnancy Birth Weight Medicine Mass index 030212 general & internal medicine 2. Zero hunger INSULIN-RESISTANCE education.field_of_study Research Support Non-U.S. Gov't Obstetrics and Gynecology GESTATIONAL DIABETES-MELLITUS 11 Medical And Health Sciences Fasting General Medicine 3. Good health PREGNANCY OUTCOME HAPO MENDELIAN RANDOMIZATION Female medicine.symptom Life Sciences & Biomedicine Adult medicine.medical_specialty Genotype Offspring Birth weight European Continental Ancestry Group Population 030209 endocrinology & metabolism Polymorphism Single Nucleotide Article White People 03 medical and health sciences Medicine General & Internal Research Support N.I.H. Extramural SDG 3 - Good Health and Well-being Early Growth Genetics (EGG) Consortium General & Internal Medicine Internal medicine Mendelian randomization Journal Article Humans Obesity GENOME-WIDE ASSOCIATION education Triglycerides Science & Technology business.industry Infant Newborn Mendelian Randomization Analysis medicine.disease BODY-MASS INDEX Endocrinology Diabetes Mellitus Type 2 COHORT PROFILE FETAL-GROWTH business Body mass index |
| Zdroj: | Tyrrell, J, Richmond, R C, Palmer, T M, Feenstra, B, Rangarajan, J, Metrusky, S, Cavadino, A, Paternoster, L, Armstrong, L L, De Silva, N M G, Wood, A R, Horikoshi, M, Geller, F, Myhre, R, Bradfield, J P, Kreiner-Møller, E, Huikari, V, Painter, J N, Hottenga, J J, Allard, C, Berry, D J, Bouchard, L, Das, S, Evans, D M, Hakonarson, H, Hayes, M G, Heikkinen, J, Hofman, A, Knight, B A, Lind, P A, McCarthy, M I, McMahon, G, Medland, S E, Melbye, M, Morris, A P, Nodzenski, M, Reichetzeder, C, Ring, S M, Sebed, S, Sengpiel, V, Sorensen, T I A, Willemsen, G, de Geus, E J C, Martin, N G, Spector, T D, Power, C, Järvelin, M-R, Bisgaard, H, Grant, S F A, Nohr, E A, Jaddoe, VW, Jacobsson, B, Murray, J C, Hocher, B, Hattersley, A T, Scholtens, D M, Davey Smith, G, Hivert, M-F, Felix, J F, Hyppönen, E, Lowe, W L, Frayling, T M, Lawlor, D A & Freathy, R M 2016, ' Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight ', JAMA-Journal of the American Medical Association, vol. 315, no. 11, pp. 1129-1140 . https://doi.org/10.1001/jama.2016.1975 Tyrrell, J, Richmond, R C, Palmer, T M, Feenstra, B, Rangarajan, J, Metrustry, S, Cavadino, A, Paternoster, L, Armstrong, L L, De Silva, N M G, Wood, A R, Horikoshi, M, Geller, F, Myhre, R, Bradfield, J P, Kreiner-Møller, E, Huikari, V, Painter, J N, Hottenga, J J, Allard, C, Berry, D J, Bouchard, L, Das, S, Evans, D M, Hakonarson, H, Hayes, M G, Heikkinen, J, Hofman, A, Knight, B, Lind, P A, McCarthy, M I, McMahon, G, Medland, S E, Melbye, M, Morris, A P, Nodzenski, M, Reichetzeder, C, Ring, S M, Sebert, S, Sengpiel, V, Sørensen, T I A, Willemsen, G, de Geus, E J C, Martin, N G, Spector, T D, Power, C, Järvelin, M R, Bisgaard, H, Grant, S F A, Nohr, E A, Jaddoe, V W, Jacobsson, B, Murray, J C, Hocher, B, Hattersley, A T, Scholtens, D M, Davey Smith, G, Hivert, M F, Felix, J F, Hyppönen, E, Lowe, W L, Frayling, T M, Lawlor, D A & Freathy, R M 2016, ' Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight ', JAMA, vol. 315, no. 11, pp. 1129-1140 . https://doi.org/10.1001/jama.2016.1975 JAMA-Journal of the American Medical Association, 315(11), 1129-1140. American Medical Association Tyrrell, J, Richmond, R C, Palmer, T M, Feenstra, B, Rangarajan, J, Metrustry, S, Cavadino, A, Paternoster, L, Armstrong, L L, De Silva, N M G, Wood, A R, Horikoshi, M, Geller, F, Myhre, R, Bradfield, J P, Kreiner-Møller, E, Huikari, V, Painter, J N, Hottenga, J-J, Allard, C, Berry, D J, Bouchard, L, Das, S, Evans, D M, Hakonarson, H, Hayes, M G, Heikkinen, J, Hofman, A, Knight, B, Lind, P A, McCarthy, M I, McMahon, G, Medland, S E, Melbye, M, Morris, A P, Nodzenski, M, Reichetzeder, C, Ring, S M, Sebert, S, Sengpiel, V, Sørensen, T I A, Willemsen, G, de Geus, E J C, Martin, N G, Spector, T D, Power, C, Järvelin, M-R, Bisgaard, H, Grant, S F A, Nohr, E A 2016, ' Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight ', JAMA, vol. 315, no. 11, pp. 1129-40 . https://doi.org/10.1001/jama.2016.1975 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION Tyrrell, J, Richmond, R C, Palmer, T M, Feenstra, B, Rangarajan, J, Metrustry, S, Cavadino, A, Paternoster, L, Armstrong, L L, De Silva, N M G, Wood, A R, Horikoshi, M, Geller, F, Myhre, R, Bradfield, J P, Kreiner-Møller, E, Huikari, V, Painter, J N, Hottenga, J-J, Allard, C, Berry, D J, Bouchard, L, Das, S, Evans, D M, Hakonarson, H, Hayes, M G, Heikkinen, J, Hofman, A, Knight, B, Lind, P A, McCarthy, M I, McMahon, G, Medland, S E, Melbye, M, Morris, A P, Nodzenski, M, Reichetzeder, C, Ring, S M, Sebert, S, Sengpiel, V, Sørensen, T I A, Willemsen, G, de Geus, E J C, Martin, N G, Spector, T D, Power, C, Järvelin, M-R, Bisgaard, H, Grant, S F A, Nohr, E A & Early Growth Genetics (EGG) Consortium 2016, ' Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight ', J A M A: The Journal of the American Medical Association, vol. 315, no. 11, pp. 1129-1140 . https://doi.org/10.1001/jama.2016.1975 JAMA, 315(11), 1129-1140. American Medical Association JAMA |
| ISSN: | 0098-7484 |
| Popis: | ImportanceNeonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain.ObjectiveTo test for genetic evidence of causal associations of maternal body mass index (BMI) and related traits with birth weight.Design, Setting, and ParticipantsMendelian randomization to test whether maternal BMI and obesity-related traits are potentially causally related to offspring birth weight. Data from 30 487 women in 18 studies were analyzed. Participants were of European ancestry from population- or community-based studies in Europe, North America, or Australia and were part of the Early Growth Genetics Consortium. Live, term, singleton offspring born between 1929 and 2013 were included.ExposuresGenetic scores for BMI, fasting glucose level, type 2 diabetes, systolic blood pressure (SBP), triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, vitamin D status, and adiponectin level.Main Outcome and MeasureOffspring birth weight from 18 studies.ResultsAmong the 30 487 newborns the mean birth weight in the various cohorts ranged from 3325 g to 3679 g. The maternal genetic score for BMI was associated with a 2-g (95% CI, 0 to 3 g) higher offspring birth weight per maternal BMI-raising allele (P = .008). The maternal genetic scores for fasting glucose and SBP were also associated with birth weight with effect sizes of 8 g (95% CI, 6 to 10 g) per glucose-raising allele (P = 7 × 10−14) and −4 g (95% CI, −6 to −2g) per SBP-raising allele (P = 1×10−5), respectively. A 1-SD ( ≈ 4 points) genetically higher maternal BMI was associated with a 55-g higher offspring birth weight (95% CI, 17 to 93 g). A 1-SD ( ≈ 7.2 mg/dL) genetically higher maternal fasting glucose concentration was associated with 114-g higher offspring birth weight (95% CI, 80 to 147 g). However, a 1-SD ( ≈ 10 mm Hg) genetically higher maternal SBP was associated with a 208-g lower offspring birth weight (95% CI, −394 to −21 g). For BMI and fasting glucose, genetic associations were consistent with the observational associations, but for systolic blood pressure, the genetic and observational associations were in opposite directions.Conclusions and RelevanceIn this mendelian randomization study, genetically elevated maternal BMI and blood glucose levels were potentially causally associated with higher offspring birth weight, whereas genetically elevated maternal SBP was potentially causally related to lower birth weight. If replicated, these findings may have implications for counseling and managing pregnancies to avoid adverse weight-related birth outcomes. |
| Databáze: | OpenAIRE |
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