Benzyl alcohol poisoning
| Autor: | Rachel A. Griffith |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Cns depression medicine.drug_physiologic_effect Infant Newborn Poison control Pharmacy Metabolic acidosis medicine.disease Infant Newborn Diseases chemistry.chemical_compound chemistry Benzyl alcohol Intensive care Pediatrics Perinatology and Child Health Injury prevention Benzyl Compounds medicine Humans business Depression (differential diagnoses) Benzyl Alcohols Benzyl Alcohol |
| Zdroj: | American journal of diseases of children (1960). 137(8) |
| ISSN: | 0002-922X |
| Popis: | Sir .—This letter is in response to Dr Lovejoy's succinct marginal comment "Fatal Benzyl Alcohol Poisoning in Neonatal Intensive Care Units: A New Concern for Pediatricians" (Journal1982;136:974-975). This syndrome consisting of metabolic acidosis, respiratory depression with progression to gasping respirations, renal failure, CNS depression, seizures, intracranial hemorrhage, and hypotension was noted in infants with intakes of 99 to 405 mg/kg/day of benzyl alcohol. 1-3 This syndrome certainly seems to be a real entity, but its description leaves the clinician with a great dilemma. Should all medications containing benzyl alcohol (or other preservatives) be eliminated from our neonatal pharmacies? Is there a "safe" intake (milligrams per kilogram per day) of benzyl alcohol? Is there a threshold effect? These are practical questions that pose concern for neonatologists and pediatricians who treat neonates. The Table gives several commonly used medications that contain benzyl alcohol. Many medications contain various other preservatives, the effects |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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