Mayaro virus induction of oxidative stress is associated with liver pathology in a non-lethal mouse model
| Autor: | Ariane Coelho Ferraz, Tales Fernando da Silva, Breno de Mello Silva, Cláudia Martins Carneiro, Cintia Lopes de Brito Magalhães, Fernanda Caetano Camini, Mayara Medeiros de Freitas Carvalho, Silvana de Queiroz Silva, José Carlos de Magalhães, Camila Carla da Silva Caetano, Rafaela Lameira Souza Lima, Letícia Trindade Almeida, Thalles de Freitas Castro |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Science 030231 tropical medicine Arthritis Alphavirus Disease Virus Replication medicine.disease_cause Article Antioxidants Virus 03 medical and health sciences 0302 clinical medicine In vivo Virology medicine Animals Humans Mice Inbred BALB C Multidisciplinary biology Alphavirus Infections business.industry medicine.disease Disease Models Animal Oxidative Stress 030104 developmental biology Liver Viral replication Host-Pathogen Interactions Immunology biology.protein Medicine Virus Activation Antibody Structural biology Reactive Oxygen Species business Oxidation-Reduction Oxidative stress |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) Scientific Reports |
| Popis: | Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations and an imbalance in redox homeostasis, culminating with oxidative stress. MAYV-infected mice revealed lower weight gain; however, the disease was self-resolving. High virus titre, neutralizing antibodies, and increased levels of aspartate and alanine aminotransferases were detected in the serum. Infectious viral particles were recovered in the liver of infected animals and the histological examination of liver tissues revealed significant increase in the inflammatory infiltrate. MAYV induced significant oxidative stress in the liver of infected animals, as well as a deregulation of enzymatic antioxidant components. Collectively, this is the first study to report that oxidative stress occurs in MAYV infection in vivo, and that it may be crucial in virus pathogenesis. Future studies are warranted to address the alternative therapeutic strategies for Mayaro fever, such as those based on antioxidant compounds. |
| Databáze: | OpenAIRE |
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