Synthesis and Non-Aqueous Medium Titrations of Some New 4-Benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives
| Autor: | Haydar Yüksek, Zafer Ocak, Şule Bahçeci, Muzaffer Alkan, Osman Üçüncü |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
4-triazol-5-one
Potentiometric titration Pharmaceutical Science Alcohol Medicinal chemistry Article Analytical Chemistry 2-Propanol lcsh:QD241-441 chemistry.chemical_compound Schiff base lcsh:Organic chemistry Drug Discovery Organic chemistry 4 5-Dihydro-1H-1 2 4-triazol-5-one Physical and Theoretical Chemistry Acetonitrile acidity acetylation Tetrabutylammonium hydroxide Aryl Organic Chemistry Dimethylformamide Isopropyl alcohol Hydrogen-Ion Concentration Triazoles potentiometric titrations Solutions chemistry Chemistry (miscellaneous) Potentiometry Molecular Medicine Titration 5-Dihydro-1H-1 methylation |
| Zdroj: | Molecules, Vol 10, Iss 8, Pp 961-970 (2005) Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules Volume 10 Issue 8 Pages 961-970 |
| ISSN: | 1420-3049 |
| Popis: | The synthesis of 3-alkyl(aryl)-4-(3-ethoxy-4-hydroxybenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3 from the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 with 3-ethoxy-4-hydroxybenzaldehyde is described. The acetylation and methylation reactions of the compounds 3 giving compounds of type 4 and 5, respectively, were investigated. The newly synthesized compounds were characterized using elemental analyses and IR, (1)H-NMR, (13)C-NMR and UV spectral data. In addition, to investigate the effects of solvents and molecular structure upon acidity,compounds 3 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide). The half-neutralization potential values and the corresponding pKa values were determined for all cases. |
| Databáze: | OpenAIRE |
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