Infective endocarditis caused by Capnocytophaga canimorsus; a case report

Autor: Takahiro Matsuoka, Kei Yamamoto, Jun Sakai, Yusuke Nishida, Kana Ohgane, Kazuhito Imanaka, Shigefumi Maesaki, Masahiro Kodana, Hideaki Oka, Hideaki Ohno, Susumu Sekine, Toru Kawamura
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Aortic valve
medicine.medical_specialty
Fulminant
030106 microbiology
Cefazolin
Case Report
Polymerase Chain Reaction
beta-Lactamases
lcsh:Infectious and parasitic diseases
Sepsis
03 medical and health sciences
Dogs
0302 clinical medicine
Aortic valve replacement
Internal medicine
medicine
Animals
Humans
Capnocytophaga canimorsus
lcsh:RC109-216
Bites and Stings
Aortic valve regurgitation
biology
business.industry
Ceftriaxone
Endocarditis
Bacterial
Middle Aged
medicine.disease
biology.organism_classification
Anti-Bacterial Agents
Infectious Diseases
medicine.anatomical_structure
Blood Culture
Heart Valve Prosthesis
Infective endocarditis
Drug susceptibility test
Gentamicins
Gram-Negative Bacterial Infections
business
Capnocytophaga
030217 neurology & neurosurgery
medicine.drug
Zdroj: BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-5 (2019)
BMC Infectious Diseases
ISSN: 1471-2334
DOI: 10.1186/s12879-019-4492-3
Popis: Background Capnocytophaga canimorsus is a gram-negative bacterium and an oral commensal in dogs and cats, but occasionally causes serious infections in humans. Septicemia is one of the most fulminant forms, but diagnosis of C. canimorsus infection is often difficult mainly because of its very slow growth. C. canimorsus infective endocarditis (IE) is rare and is poorly understood. Since quite a few strains produce β-lactamase, antimicrobial susceptibility is pivotal information for adequate treatment. We herein report a case with C. canimorsus IE and the results of drug susceptibility test. Case presentation A 46-year-old man had a dog bite in his left hand 3 months previously. The patient was referred to our hospital for fever (body temperature > 38 °C), visual disturbance, and dyspnea. Echocardiography showed aortic valve regurgitation and vegetation on the leaflets. IE was diagnosed, and we initially administered cefazolin and gentamycin assuming frequently encountered microorganisms and the patient underwent aortic valve replacement. C. canimorsus was detected in the aortic valve lesion and blood cultures. It was also identified by 16S ribosome DNA sequencing. Ceftriaxone were started and continued because disk diffusion test revealed the isolate was negative for β-lactamase and this case had cerebral symptoms. The patient successfully completed antibiotic treatment following surgery. Conclusions We diagnosed C. canimorsus sepsis and IE by extended-period blood cultures and 16S ribosome DNA sequencing by polymerase chain reaction, and successfully identified its drug susceptibility.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje