Does progesterone supplementation improve pregnancy rates in clomiphene citrate and intrauterine insemination treatment cycles?
| Autor: | Nichole M. Barker, Sonia Elguero, Bansari Patel, Allison M. Wyman, William W. Hurd, James H. Liu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Rate Endocrinology Diabetes and Metabolism media_common.quotation_subject Fertility Luteal Phase Luteal phase Clomiphene Young Adult Endocrinology Ovulation Induction Pregnancy medicine Humans Insemination Artificial Progesterone Retrospective Studies Unexplained infertility media_common Gynecology Intrauterine insemination Obstetrics business.industry Obstetrics and Gynecology Retrospective cohort study Fertility Agents Female Odds ratio medicine.disease Confidence interval Treatment Outcome Drug Therapy Combination Female business Infertility Female |
| Zdroj: | Gynecological Endocrinology. 31:229-232 |
| ISSN: | 1473-0766 0951-3590 |
| DOI: | 10.3109/09513590.2014.981803 |
| Popis: | To investigate the effect of empiric use of luteal phase progesterone supplementation to improve endometrial receptivity in women undergoing treatment with clomiphene citrate in combination with intrauterine insemination (CC-IUI).Retrospective cohort analysis.University fertility center.426 CC-IUI cycles from 292 patients with unexplained infertility.Patients were treated with micronized intravaginal progesterone 100 mg twice daily beginning approximately three days after CC-IUI.Clinical pregnancy per initiated cycle as defined by presence of fetal heart rate on ultrasound.Clinical pregnancy rate was higher in patients receiving luteal phase support compared to patients not receiving luteal phase support (odds ratio: 2.04; 95% confidence interval: 1.01-4.14) after adjusting for all factors in the analysis using a multivariate logistic regression model. Age at the start of the cycle, BMI and CC dose were not shown to have an effect on clinical pregnancy rates. Patients with endometrial lining (EML) thickness 6-8 mm and8 mm had increased clinical pregnancy rates compared to EML6 mm independent of luteal phase progesterone use. Patients who appear to receive the greatest benefit of progesterone supplementation are in the 6-8 mm EML cohort.Luteal phase progesterone supplementation in CC-IUI cycles can improve endometrial receptivity as judged by the improved clinical pregnancy rates as the primary outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|