Proof of concept of MRI-guided tracked radiation delivery: tracking one-dimensional motion
| Autor: | Sjoerd P M Crijns, Bas W. Raaymakers, J.J.W. Lagendijk |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Computer science
Aperture Movement medicine.medical_treatment Image processing Radiation Imaging phantom Feedback Compensation (engineering) law.invention Planned Dose law medicine Humans Radiology Nuclear Medicine and imaging Computer vision Simulation Motion compensation Radiological and Ultrasound Technology Phantoms Imaging business.industry Radiation dose Cancer Collimator medicine.disease Magnetic Resonance Imaging Radiation therapy Artificial intelligence business Radiotherapy Image-Guided |
| Zdroj: | Physics in Medicine and Biology. 57:7863-7872 |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/0031-9155/57/23/7863 |
| Popis: | In radiotherapy one aims to deliver a radiation dose to a tumour with high geometrical accuracy while sparing organs at risk (OARs). Although image guidance decreases geometrical uncertainties, treatment of cancer of abdominal organs is further complicated by respiratory motion, requiring intra-fraction motion compensation to fulfil the treatment intent. With an ideal delivery system, the optimal method of intra-fraction motion compensation is to adapt the beam collimation to the moving target using a dynamic multi-leaf collimator (MLC) aperture. The many guidance strategies for such tracked radiation delivery tested up to now mainly use markers and are therefore invasive and cannot deal with target deformations or adaptations for OAR positions. We propose to address these shortcomings using the online MRI guidance provided by an MRI accelerator and present a first step towards demonstration of the technical feasibility of this proposal. The position of a phantom subjected to one-dimensional (1D) periodic translation was tracked using a fast 1D MR sequence. Real-time communication with the MR scanner and control of the MLC aperture were established. Based on the time-resolved position of the phantom, tracked radiation delivery to the phantom was realized. Dose distributions for various delivery conditions were recorded on a gafchromic film. Without motion a sharply defined dose distribution is obtained, whereas considerable blur occurs for delivery to a moving phantom. With compensation for motion, the sharpness of the dose distribution is nearly restored. The total latency in our motion management architecture is approximately 200 ms. Combination of the recorded phantom and aperture positions with the planned dose distribution enabled the reconstruction of the delivered dose in all cases, which illustrates the promise of online dose accumulation and confirms that latency compensation could further enhance our results. For a simple 1D tracked delivery scenario, the technical feasibility of MRI-guided tracked radiation delivery is confirmed. More generic tracking scenarios require advanced MRI, leading to increased acquisition time and more challenging image processing problems. Latency compensation is therefore an important subject of future investigations. |
| Databáze: | OpenAIRE |
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