The CD4+CD28null and the regulatory CD4+CD25High T-cell phenotypes in patients with ulcerative colitis during active and quiescent disease, and following colectomy
| Autor: | Hiroto Miwa, Koji Yoshida, Yoko Yokoyama, S Nakamura, Koji Kamikozuru, Hiroki Ikeuchi, Kyouichi Kato, Kazuko Nagase, Takayuki Matsumoto, Ken Fukunaga, Masaki Iimuro, Risa Kikuyama, Yoshio Ohda, Nobuyuki Hida |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
T cell
medicine.medical_treatment Immunology Cell Separation Biology T-Lymphocytes Regulatory Biochemistry Immunophenotyping CD28 Antigens medicine Humans Immunology and Allergy IL-2 receptor Colitis Molecular Biology Colectomy Interleukin-2 Receptor alpha Subunit CD28 Hematology Flow Cytometry medicine.disease Ulcerative colitis Phenotype medicine.anatomical_structure CD4 Antigens Colitis Ulcerative |
| Zdroj: | Cytokine. 56:466-470 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2011.06.021 |
| Popis: | The CD4+CD25High T-cell phenotype has an essential immunoregulatory role, while the CD4+CD28null T-cell reflects immune pathology. We investigated the profiles of the CD4+CD25High and the CD4+CD28null T-cell phenotypes in patients with ulcerative colitis (UC) during active and quiescent phases as well as following colectomy. Fifty-nine UC patients, 34 active (UCa) and 25 quiescent (UCq) together with 19 healthy controls (HC) were included. Ten of 34 UCa patients underwent colectomy due to unremitting UC (UCo). Immunohistochemical phenotypic of the peripheral blood lymphocytes bearing CD4, CD25 or CD28 was done for analyzes by a multiparameter fluorescence activated cell sorting technique. The expression of the CD4+CD25High phenotype was higher in UCq (P |
| Databáze: | OpenAIRE |
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