Analysis of Carbon-Based Microelectrodes for Neurochemical Sensing

Autor: Aaron E. Rusheen, Felicia S. Manciu, Jose Guerrero, Jonathan R. Tomshine, Abbas Z. Kouzani, Deidra Hodges, Kendall H. Lee, Yoonbae Oh, Kevin E. Bennet, Abhijeet S. Barath
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Graft Rejection
Materials science
Scanning electron microscope
Calcineurin Inhibitors
Nanotechnology
02 engineering and technology
engineering.material
Electrochemistry
lcsh:Technology
01 natural sciences
Article
boron-doped diamond thin film
carbon fiber
Abatacept
symbols.namesake
Coating
Humans
General Materials Science
Thin film
lcsh:Microscopy
lcsh:QC120-168.85
lcsh:QH201-278.5
lcsh:T
Carbonization
Calcineurin
010401 analytical chemistry
Diamond
021001 nanoscience & nanotechnology
0104 chemical sciences
Microelectrode
lcsh:TA1-2040
fast-scan cyclic voltammetry (FSCV)
symbols
engineering
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
scanning electron microscopy (SEM)
confocal Raman spectroscopy
lcsh:Engineering (General). Civil engineering (General)
0210 nano-technology
Raman spectroscopy
lcsh:TK1-9971
Zdroj: Materials
Volume 12
Issue 19
Materials, Vol 12, Iss 19, p 3186 (2019)
ISSN: 1996-1944
DOI: 10.3390/ma12193186
Popis: The comprehensive microscopic, spectroscopic, and in vitro voltammetric analysis presented in this work, which builds on the well-studied properties of carbon-based materials, facilitates potential ways for improvement of carbon fiber microelectrodes (CFMs) for neuroscience applications. Investigations by both, scanning electron microscopy (SEM) and confocal Raman spectroscopy, confirm a higher degree of structural ordering for the fibers exposed to carbonization temperatures. An evident correlation is also identified between the extent of structural defects observed from SEM and Raman results with the CFM electrochemical performance for dopamine detection. To improve CFM physico-chemical surface stability and increase its mechanical resistance to the induced compressive stress during anticipated in vivo tissue penetration, successful coating of the carbon fiber with boron-doped diamond (BDD) is also performed and microspectroscopically analyzed here. The absence of spectral shifts of the diamond Raman vibrational signature verifies that the growth of an unstrained BDD thin film was achieved. Although more work needs to be done to identify optimal parameter values for improved BDD deposition, this study serves as a demonstration of foundational technology for the development of more sensitive electrochemical sensors, that may have been impractical previously for clinical applications, due to limitations in either safety or performance.
Databáze: OpenAIRE
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