Hyperthermic intraperitoneal chemotherapy leads to an anticancer immune response via exposure of cell surface heat shock protein 90
| Autor: | S Pommier, Proics E, Jean-Ehrland Ricci, Laura Mondragón, Barbara Zunino, Camila Rubio-Patiño, Elodie Villa, Johanna Chiche, Ophélie Meynet, Bereder Jm, Michel Carles, Cornille A |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Hyperthermia Cancer Research Colorectal cancer Cell Biology Cancer Vaccines 03 medical and health sciences 0302 clinical medicine Immune system Cell Line Tumor Heat shock protein Genetics medicine Animals Humans HSP90 Heat-Shock Proteins Molecular Biology Peritoneal Neoplasms Mice Inbred BALB C Cell Membrane Dendritic Cells Hyperthermia Induced medicine.disease Combined Modality Therapy Xenograft Model Antitumor Assays Coculture Techniques Hsp70 030104 developmental biology medicine.anatomical_structure Cell culture 030220 oncology & carcinogenesis Immunology Cancer research Hyperthermic intraperitoneal chemotherapy |
| Zdroj: | Oncogene. 35:261-268 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/onc.2015.82 |
| Popis: | The occurrence of peritoneal carcinomatosis is a major cause of treatment failure in colorectal cancer and is considered incurable. However, new therapeutic approaches have been proposed, including cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Although HIPEC has been effective in selected patients, it is not known how HIPEC prolongs a patient's lifespan. Here, we have demonstrated that HIPEC-treated tumor cells induce the activation of tumor-specific T cells and lead to vaccination against tumor cells in mice. We have established that this effect results from the HIPEC-mediated exposure of heat shock protein (HSP) 90 at the plasma membrane. Inhibition or blocking of HSP90, but not HSP70, prevented the HIPEC-mediated antitumoral vaccination. Our work raises the possibility that the HIPEC procedure not only kills tumor cells but also induces an efficient anticancer immune response, therefore opening new opportunities for cancer treatment. |
| Databáze: | OpenAIRE |
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