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OBJECTIVES: Post-amputation, clinical markers of pain-related peripheral and central nervous system hypersensitivity remain understudied. This study aimed to identify whether adults with post-amputation pain demonstrate greater pain sensitivity in primary (i.e., amputated-region) and secondary (i.e., non-amputated-region) sites, as compared to pain-free peers and controls with intact limbs. METHODS: Ninety-four participants post-unilateral, transtibial amputation (59 with pain, 35 pain-free) and 39 controls underwent pain-pressure threshold testing at 10 sites. Pain pressure-thresholds were normalized to sex-specific control data using z-score conversions. Normalized primary- and secondary-site pain-pressure thresholds were compared between groups using multivariate analysis of variance (p |
