Spermidine-induced improvement of memory consolidation involves PI3K/Akt signaling pathway
| Autor: | Carlos Fernando Mello, Carolina Coelho Ilha Valin, Maribel Antonello Rubin, Micheli M. Pillat, Bruna Amanda Girardi, Fernanda Tibolla Viero, Arithane Lorena Wendel, Shaiana Beck Fabbrin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Spermidine Hippocampus Tropomyosin receptor kinase B Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine Memory Neurotrophic factors Conditioning Psychological mental disorders Animals Receptor trkB Rats Wistar Protein kinase B PI3K/AKT/mTOR pathway Memory Consolidation Chemistry Brain-Derived Neurotrophic Factor General Neuroscience Fear Polyamine binding Rats 030104 developmental biology nervous system NMDA receptor Memory consolidation Proto-Oncogene Proteins c-akt Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Brain Research Bulletin. 164:208-213 |
| ISSN: | 0361-9230 |
| Popis: | Spermidine (SPD) is an endogenous polyamine that plays a facilitatory role in memory acquisition and consolidation. Memory consolidation occurs immediately after learning and again around 3-6 hours later. Current evidence indicates that the polyamine binding site at the NMDA receptor (NMDAr) mediates the effects of SPD on memory. While NMDAr activation increases brain-derived neurotrophic factor (BDNF) release, no study has investigated whether BDNF-activated signaling pathways, such as the phosphatidylinositol 3-kinase (PI3K)/Akt pathway play a role in SPD-induced improvement of memory consolidation. Therefore, the aim of the current study was to evaluate whether the TrkB receptor and the PI3K/Akt pathway are involved in the facilitatory effect of SPD on memory consolidation. Male Wistar rats were trained in the contextual conditioned fear task. SPD, ANA-12 (TrkB antagonist), and LY294002 (PI3K inhibitor) were administered immediately after training. The animals were tested 24 h after training. We found that SPD improved fear memory consolidation and that both ANA-12 and LY294002 prevented the facilitatory effect of SPD on memory. These results suggest that SPD-induced improvement of memory consolidation involves the activation of the TrkB receptor and PI3K/Akt pathway. |
| Databáze: | OpenAIRE |
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