6-Hydroxydopamine lesion of the rat prefrontal cortex impairs motor initiation but not motor execution
| Autor: | Werner J. Schmidt, Michael Bubser, Wolfgang Hauber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Prefrontal Cortex Motor program Motor Activity Rats Sprague-Dawley Lesion Norepinephrine Prefrontal cortex 6-Hydroxydopamine Dopamine Noradrenaline Reaction and movement times Rat Neurochemical Internal medicine Reaction Time medicine Animals Präfrontaler Cortex Dopamin Reaktionszeit Ratte Biogenic Monoamines Oxidopamine Prefrontal cortex Chromatography High Pressure Liquid business.industry General Neuroscience Motor control Body movement Rats medicine.anatomical_structure Endocrinology medicine.symptom business Neuroscience medicine.drug Motor cortex |
| Zdroj: | Scopus-Elsevier |
| DOI: | 10.18419/opus-1797 |
| Popis: | We examined the effects of bilateral 6-hydroxydopamine (6-OHDA) lesions of the medial prefrontal cortex (PFC) in rats on motor initiation and execution in a simple reaction time task. Reaction times (RT) and movement times (MT) were measured in trained rats on four pre- and postoperative days. Animals with 6-OHDA lesions were selectively impaired on motor initiation as measured by a significant increase in RT on each postoperative day. Motor execution was intact postoperatively, since MT was not altered. Neurochemical analysis revealed a significant depletion of prefrontal dopamine (DA) and noradrenaline (NA) in lesioned animals. It was concluded that DA and, to a lesser extent, NA in the rat PFC were involved in monitoring RT performance. |
| Databáze: | OpenAIRE |
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