Prognostic significance of p16INK4a/p53 in Tunisian patients with breast carcinoma
Autor: | Ali Gargouri, Sondes Karray-Chouayekh, Sami Baccouche, Raja Mokdad-Gargouri, Mounir Frikha, Tahia Sellami-Boudawara, Abdelmajid Khabir, Jamel Daoud, Rachid Jlidi |
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Rok vydání: | 2011 |
Předmět: |
Adult
Oncology medicine.medical_specialty Tunisia Histology Breast Neoplasms Kaplan-Meier Estimate Biology Breast cancer Infiltrating ductal carcinoma Internal medicine Biomarkers Tumor medicine Humans Statistical analysis neoplasms Cyclin-Dependent Kinase Inhibitor p16 Aged Proportional Hazards Models bcl-2-Associated X Protein Aged 80 and over Carcinoma Ductal Breast Proto-Oncogene Proteins c-mdm2 Cell Biology General Medicine Middle Aged Cell cycle Prognosis medicine.disease Proto-Oncogene Proteins c-bcl-2 Receptors Estrogen Apoptosis Multivariate Analysis biology.protein Immunohistochemistry Mdm2 Female Tumor Suppressor Protein p53 Receptors Progesterone Breast carcinoma |
Zdroj: | Acta Histochemica. 113:508-513 |
ISSN: | 0065-1281 |
Popis: | Infiltrating ductal carcinoma (IDC) of the breast is a result of genetic alterations that affect the regulation of the cell cycle check-point and apoptosis. The aim of the present study was analysis using immunohistochemical localization of mouse double minute-2 (mdm2), p16INK4a, p53, bax and bcl-2 markers in Tunisian patients with breast IDC and to determine if there was correlation with the major clinico-pathological parameters and with survival of patients. We showed that the expression of p53, p16INK4a, mdm2, bcl-2, and bax was observed in 46.3%, 20.7%, 38%, 50% and 11.9% of cases, respectively. Statistical analysis revealed that positive expression of mdm2 was associated with larger tumors (P=0.013), whereas bax positivity was more prevalent in younger patients and in tumors of smaller size (P=0.008 and P=0.012 respectively). Furthermore, the expression of p16INK4a correlated with advanced grade (P0.0001), triple negative tumors (ER-/PR-/HER2-, P=0.001) and mdm2 expression (P=0.017). The absence of nuclear p53 accumulation was predictive of good prognosis as well as when it was associated with negative expression of p16INK4a. Our findings suggest that among the biomarkers tested, p16INK4a might have a useful clinical and prognostic significance in infiltrating ductal carcinoma of the breast. |
Databáze: | OpenAIRE |
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