Engineering approaches for effective therapeutic applications based on extracellular vesicles
| Autor: | Deok Ho Kim, Yong Woo Cho, Byeong Hoon Oh, Van Dat Bui, Seunglee Kwon, Jae Hyung Park, Minjae Do, Yeari Song, Sol Shin, Eun Sook Lee, Dong-Gyu Jo |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
business.industry Pharmaceutical Science 02 engineering and technology Cell Communication Disease pathogenesis 021001 nanoscience & nanotechnology Extracellular vesicles 03 medical and health sciences Extracellular Vesicles Drug Delivery Systems Biological significance Medicine 0210 nano-technology business Neuroscience 030304 developmental biology |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 330 |
| ISSN: | 1873-4995 |
| Popis: | The biological significance of extracellular vesicles (EVs) as intercellular communication mediators has been increasingly revealed in a wide range of normal physiological processes and disease pathogenesis. In particular, regenerative and immunomodulatory EVs hold potential as innate biotherapeutics, whereas pathological EVs are considered therapeutic targets for inhibiting their bioactivity. Given their ability to transport functional cargos originating from the source cells to target cells, EVs can also be used as a therapeutic means to deliver drug molecules. This review aims to provide an updated overview of the key engineering approaches for better exploiting EVs in disease intervention. The emphasis is lying on the preconditioning methods for therapeutic EVs, drug loading and targeting technologies for carrier EVs, and activity control strategies for pathological EVs. |
| Databáze: | OpenAIRE |
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