Reprint of 'The role of cytoskeleton in the regulation of vascular endothelial barrier function' [Microvascular Research 76 (2008) 202–207]
| Autor: | Alexander D. Verin, Natalia V. Bogatcheva |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Endothelium
Vascular permeability Biology Microtubules Biochemistry Article Capillary Permeability Stress Fibers medicine Animals Humans Transcellular Cytoskeleton S1PR1 Barrier function Cell Biology Actins Cell biology Vascular endothelial growth factor B Intercellular Junctions medicine.anatomical_structure Paracellular transport Endothelium Vascular Cardiology and Cardiovascular Medicine Signal Transduction |
| Zdroj: | Microvasc Res |
| ISSN: | 0026-2862 |
| Popis: | The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cell monolayer in quiescent endothelium, and to enable the disintegration of the formed barrier in response to various agonists. Vascular permeability is defined by the combination of transcellular and paracellular pathways, with the latter being a major contributor to the inflammation-induced barrier dysfunction. This review will analyze the cytoskeletal elements, which reorganization affects endothelial permeability, and emphasize signaling mechanisms with barrier-protective or barrier-disruptive potential. |
| Databáze: | OpenAIRE |
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