The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury
| Autor: | Jing-Yu Zhao, Fan Song, Han Liu, Tian Jian Lu, Shaobao Liu, Changchun Ji, Shao-Ming Liu, Li-Ping Huang, Feng Xu, Guoyou Huang, Siwang Wang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Side effect Acupuncture Therapy Stimulation Apoptosis Myocardial Reperfusion Injury Disease 030204 cardiovascular system & hematology medicine.disease_cause Protective Agents General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine Acupuncture Medicine Animals Myocytes Cardiac General Pharmacology Toxicology and Pharmaceutics Pathological business.industry General Medicine medicine.disease Rats Oxidative Stress 030104 developmental biology Cardiology business Reperfusion injury Acupuncture Points Gels Oxidative stress |
| Zdroj: | Life sciences. 211 |
| ISSN: | 1879-0631 |
| Popis: | Aims Prevention and treatment of myocardial ischemia-reperfusion (I/R) injury has for many years been a hot topic in treating ischemic heart disease. As one of the most well-known methods of complementary and alternative medicine, acupuncture has attracted increasing interest in preventing myocardial I/R injury due to its remarkable effectiveness and minimal side effect. However, traditional acupuncture approaches are limited by cumbersome execution, high labor costs and inevitable pain caused by frequent stimulation. Therefore, in this work, we aimed to develop a novel acupoint gel embedding approach and investigated its role in protecting against myocardial I/R injury in rats. Main methods Gels were embedded at bilateral Neiguan (PC6) points of rats and their protective effects against myocardial I/R injury evaluated in terms of changes in histomorphology, myocardial enzymology, antioxidant capacity, anti-inflammatory response, and anti-apoptosis of cells. Key findings We found that the approach of acupoint gel embedding could significantly reduce myocardial infarcted size, repair pathological changes, mitigate oxidative stress damage and inflammatory response, as well as inhibit apoptosis of cardiomyocytes. Such cardioprotective effects were found to be associated with Notch-1/Jagged-1 signaling pathway. Significance The proposed approach of acupoint gel embedding has advantages in continuous acupoint stimulation, dosing controls, and no side effects in the course of treatment, as well as in reducing the pain caused by frequent acupuncture. It can form an alternative therapy to not only protect against myocardial I/R injury but also hold great potential in treating other diseases in the future. |
| Databáze: | OpenAIRE |
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