Next generation tau models in Alzheimer's disease research – virus based gene delivery systems
| Autor: | V. Brezováková, B. Valachová, S. Jadhav, I. Zimová, V. Cubinková, Z. Kostecká, R. Szabó |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Amyloid tau Proteins Disease Gene delivery Biology Models Biological Adenoviridae Viral vector Alzheimer's disease research 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Virology medicine Animals Humans Dementia Cognitive decline Organisms Genetically Modified General Medicine medicine.disease 030104 developmental biology Infectious Diseases Tauopathy Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Acta virologica. 61:13-21 |
| ISSN: | 1336-2305 |
| DOI: | 10.4149/av_2017_01_13 |
| Popis: | Alzheimer's disease (AD) the most common form of dementia is characterized by cognitive decline and progressive loss of neurons in the central nervous system. Despite huge scientific progress, there are only few animal models that recapitulate at least majority of the AD pathology and related symptomatology. Therefore, alternative methods to develop animal models for neurodegenerative diseases are constantly explored. Recently, recombinant adeno-associated viruses (AAVs) are widely used viral vectors in development of novel models for neurodegenerative diseases. AAV vectors expressing full length, mutant or truncated forms of tau demonstrate early and robust pathology characterized by AT8 positivity, NFT formation, motor and cognitive deficits. Furthermore, AAVs have been used in expression of tau in amyloid rodent models thus developing both lesions of amyloid and tau therefore recapitulating AD like features. Major advantage of AAV as a delivery system is the site specific expression of tau, mostly in hippocampus and cortex, and thus elimination of unwanted ectopic transgene expression. These novel models may help in better understanding of AD etiopathogenesis and provide a platform for development and testing of disease modifying drugs in preclinical efficacy studies. |
| Databáze: | OpenAIRE |
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