Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium
| Autor: | Joanne M. Jordan, Virginia B. Kraus, Jordan B. Renner, David J. Hunter, David E Hargrove |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Aging medicine.medical_specialty Immunology Type II collagen Context (language use) Urine Osteoarthritis General Biochemistry Genetics and Molecular Biology Body Mass Index Specimen Handling 03 medical and health sciences 0302 clinical medicine Rheumatology N-terminal telopeptide Reference Values Internal medicine medicine Humans Immunology and Allergy Aged Pain Measurement 030203 arthritis & rheumatology business.industry Age Factors Middle Aged medicine.disease Reference intervals Case-Control Studies Physical therapy Female business Body mass index Algorithms Biomarkers 030217 neurology & neurosurgery Type I collagen |
| Zdroj: | Annals of the Rheumatic Diseases. 76:179-185 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | ObjectiveTo establish reference intervals for osteoarthritis (OA)-related biomarkers used in the Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium Project.MethodsA total of 129 ‘multijoint controls’ were selected from 2722 African-American and Caucasian men and women in the Johnston County Osteoarthritis Project. The majority (79%) of those eligible (with biospecimens and baseline data) also had one or more follow-up evaluations 5–15 years later. Multijoint controls were selected to be free of radiographic hand, hip, knee and lumbar spine osteoarthritis (OA), to have no knee or hip symptoms, and minimal hand and spine symptoms at all available time points. Eighteen biomarkers were evaluated in serum (s) and/or urine (u) by ELISA. Reference intervals and partitioning by gender and race were performed with EP Evaluator software.ResultsControls were 64% women, 33% African-Americans, mean age 59 years and mean body mass index 29 kg/m2. Three biomarkers were associated with age: sHyaluronan (positively), sN-terminal propeptide of collagen IIA (positively) and sCol2-3/4 C-terminal cleavage product of types I and II collagen (negatively). Exploratory analyses suggested that separate reference intervals may be warranted on the basis of gender for uC-terminal cross-linked telopeptide of type II collagen (uCTXII), sMatrix metalloproteinase-3, uNitrated type II collagen degradation fragment (uCol2-1 NO2) and sHyaluronan, and on the basis of race for uCTXII, sCartilage oligomeric matrix protein, sC-terminal cross-linked telopeptide of type I collagen and uCol2-1 NO2.ConclusionsTo our knowledge, this represents the best and most stringent control group ever assayed for OA-related biomarkers. These well-phenotyped controls, representing a similar age demographic to that of the OA Initiative-FNIH main study sample, provide a context for interpretation of OA subject biomarker data. The freely available data set also provides a reference for future human studies. |
| Databáze: | OpenAIRE |
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