Quantitative MRI demonstrates abnormalities of the third ventricle subventricular zone in neurofibromatosis type-1 and sporadic paediatric optic pathway glioma
| Autor: | Patricia O’Hare, Felice D'Arco, Jessica Cooper, Victoria Smith, Kshitij Mankad, Darren Hargrave, Bronwen C Walters, Natalie R. Boonzaier, Patrick W. Hales, Chris A. Clark, Ramneek Kaur, Alki Liasis |
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| Rok vydání: | 2020 |
| Předmět: |
Optic Nerve Glioma
musculoskeletal diseases Pathology medicine.medical_specialty Neurofibromatosis 1 Visual acuity Cognitive Neuroscience Optic pathway glioma Third ventricle subventricular zone Subventricular zone Grey matter lcsh:Computer applications to medicine. Medical informatics lcsh:RC346-429 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Lateral Ventricles Bayesian multivariate linear regression medicine Humans Effective diffusion coefficient 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Quantitative magnetic resonance imaging Neurofibromatosis Child lcsh:Neurology. Diseases of the nervous system ComputingMethodologies_COMPUTERGRAPHICS Third Ventricle Neurofibromatosis type-1 Third ventricle business.industry 05 social sciences Infant Regular Article medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Cerebral blood flow Paediatric lcsh:R858-859.7 Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 28, Iss, Pp 102447-(2020) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102447 |
| Popis: | Graphical abstract Highlights • MRI provides supporting evidence of third ventricle subventricular involvement in OPG. • Third ventricle subventricular zone ADC and CBF differs between NF1 and sporadic OPG. • Third ventricle subventricular zone ADC correlates with vision in sporadic OPG. Background The subventricular zone of the third ventricle (TVZ) is a germinal stem cell niche, identified as the possible location of optic pathway glioma (OPG) cell origin. Paediatric OPGs are predominantly diagnosed as low-grade astrocytomas, which are either sporadic or are associated with neurofibromatosis type-1 (NF1). These tumours often cause a significant impairment to visual acuity (VA). Infiltrative/invasive tumour activity is associated with increased apparent diffusion coefficient (ADC) and cerebral blood flow (CBF). This study aimed to determine whether TVZ imaging features differed between sporadic-OPG, NF1-OPG and controls, and whether the ADC and CBF profile at the germinal stem cell niche (the TVZ) correlated with the primary outcome of VA. Methods ADC and CBF MRI data were acquired from 30 paediatric OPG patients (median age 6 years; range 8 months–17 years), along with VA measurements, during clinical surveillance of their tumour. Values for mean ADC and maximum CBF were measured at the TVZ, and normalized to normal-appearing grey matter. These values were compared between the two OPG groups and the healthy control subjects, and multivariate linear regression was used to test the linear association between these values and patient’s VA. Results In the TVZ, normalized mean ADC was higher in NF1-associated OPG patients (N = 15), compared to both sporadic OPG patients (N = 15; p = 0.010) and healthy controls (N = 14; p |
| Databáze: | OpenAIRE |
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