Window of Opportunity for Neuroprotection with an Antioxidant, Allene Oxide Synthase, after Hypoxia-Ischemia in Adult Male Rats
| Autor: | Sam Mathai, Alistair J. Gunn, Ralph Andrew Backhaus, Jian Guan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Hippocampus Brain damage Striatum Biology medicine.disease_cause Neuroprotection Antioxidants Physiology (medical) Internal medicine medicine Animals Pharmacology (medical) Rats Wistar Pharmacology Microglia Age Factors Original Articles Rats Cortex (botany) Intramolecular Oxidoreductases Psychiatry and Mental health Infusions Intraventricular Neuroprotective Agents Endocrinology medicine.anatomical_structure nervous system Apoptosis Anesthesia Hypoxia-Ischemia Brain medicine.symptom Oxidative stress |
| Zdroj: | CNS Neuroscience & Therapeutics. 18:887-894 |
| ISSN: | 1755-5930 |
| DOI: | 10.1111/cns.12004 |
| Popis: | Summary Aims Oxidative stress is an early event in the cascade leading in neuronal damage after hypoxic–ischemic (HI) brain injury. In the present study, we examined the dose response and window of opportunity for neuroprotection after HI injury with Allene Oxide Synthase (AOS), an anti-oxidative enzyme of the member of cytochrome P450 family. Methods Adult male rats received intra-cerebro-ventricular infusions of either saline (vehicle) or AOS (1 μg or 10 μg or 100 μg per rat, intracerebroventricular n = 16 all groups) either 45 min or 3 h after unilateral HI brain injury. Brains were collected 5 days later. The extent of brain damage, neuronal survival, apoptosis, and glial reactions were assessed in the striatum, hippocampus, and cortex. Results Allene Oxide Synthase was associated with reduced neuronal damage scores when given 45 min, but not 3 h, after HI injury (P |
| Databáze: | OpenAIRE |
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