Antiobesity effect of Tamarindus indica L. pulp aqueous extract in high-fat diet-induced obese rats
Autor: | Zulkhairi Amom, Khairul Kamilah Abdul Kadir, Norhaizan Mohd Esa, Zamree Md Shah, Rasadah Mat Ali, Azrina Azlan, Khairunnuur Fairuz Azman |
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Rok vydání: | 2011 |
Předmět: |
Blood Glucose
Leptin Male medicine.medical_specialty Normal diet Adipose tissue Diet High-Fat Rats Sprague-Dawley Eating chemistry.chemical_compound Weight loss Internal medicine Tamarindus medicine Animals Insulin Obesity Triglyceride Plant Extracts Body Weight Fatty liver medicine.disease Rats Endocrinology chemistry Molecular Medicine Anti-Obesity Agents medicine.symptom Steatosis Lipoprotein |
Zdroj: | Journal of Natural Medicines. 66:333-342 |
ISSN: | 1861-0293 1340-3443 |
Popis: | Obesity and overweight are associated with atherosclerosis, fatty liver, hyperlipemia, diabetes mellitus, and various types of cancer. The global prevalence of overweight and obesity has reached epidemic proportions. Here, we investigated the effect of Tamarindus indica pulp aqueous extract (TIE) in diet-induced obese Sprague-Dawley rats. The animals were divided into five groups and labeled as follows: the normal control (NC) group received normal diet; the positive control (PC) group received high-fat diet; and the TIE 5, 25, and 50 groups, after the induction of obesity via a high-fat diet, received TIE at 5, 25, or 50 mg/kg orally for 10 weeks. It was observed that TIE decreased the levels of plasma total cholesterol, low-density lipoprotein (LDL), and triglyceride, and increased high-density lipoprotein (HDL), with the concomitant reduction of body weight. Moreover, TIE decreased plasma leptin and reduced fatty acid synthase (FAS) activity and enhanced the efficiency of the antioxidant defense system. TIE exhibits antiobesity effects, as indicated by a significant reduction in adipose tissue weights, as well as lowering the degree of hepatic steatosis in the obesity-induced rats. The extract possesses hepatoprotective activity, as it reversed the plasma liver enzymes level elevation prior to the high-fat diet. In conclusion, TIE improved obesity-related parameters in blood, liver, and adipose tissue in a rat model and suppressed obesity induced by a high-fat diet, possibly by regulating lipid metabolism and lowering plasma leptin and FAS levels. A dose-dependant effect of TIE is detected, where TIE at 50 mg/kg showed the most prominent effect, followed by TIE at 25 mg/kg and, subsequently, 5 mg/kg. |
Databáze: | OpenAIRE |
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