Characterization of the solution degradation products of histrelin, a gonadotropin releasing hormone (LH/RH) agonist
| Autor: | Mary Lou Cotter, Charles J. Shaw, Roxanne E. Naldi, John R. Lloyd, Alan R. Oyler, David A. Graden |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Agonist
Aqueous solution Histrelin medicine.drug_class Chemistry Molecular Sequence Data Pharmaceutical Science Gonadotropin-releasing hormone Medicinal chemistry Serine Gonadotropin-Releasing Hormone Solutions Biochemistry medicine Peptide bond Infusions Parenteral Amino Acid Sequence Racemization Histidine Chromatography High Pressure Liquid medicine.drug |
| Zdroj: | Journal of pharmaceutical sciences. 80(3) |
| ISSN: | 0022-3549 |
| Popis: | The degradation products of histrelin (1, less than Glu-His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt) were determined in aqueous solution at pH 5.4 and 87 degrees C over an 18-day period (47% degradation). These degradation products (2-5) resulted from the cleavage of less than Glu-His and Trp-Ser peptide bonds, His-Trp diketopiperazine formation, and racemization of serine and histidine residues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text