Developmental Trajectories of Executive and Verbal Processes in Children with Phenylketonuria
| Autor: | Zoë Hawks, Neco X Johnson, Desirée A. White, Michael J. Strube, Dorothy K. Grange |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Adolescent Neuropsychological Tests Article 050105 experimental psychology Developmental psychology Executive Function Young Adult 03 medical and health sciences Fluency 0302 clinical medicine Phenylketonurias Developmental and Educational Psychology Humans Verbal fluency test Cognitive Dysfunction 0501 psychology and cognitive sciences Young adult Child Cognitive impairment Verbal Behavior Extramural 05 social sciences nutritional and metabolic diseases Neuropsychology and Physiological Psychology Developmental trajectory Metabolic control analysis Female Psychology Phenylalanine metabolism 030217 neurology & neurosurgery |
| Zdroj: | Developmental Neuropsychology. 43:207-218 |
| ISSN: | 1532-6942 8756-5641 |
| DOI: | 10.1080/87565641.2018.1438439 |
| Popis: | Phenylketonuria (PKU) is a hereditary disorder characterized by disrupted phenylalanine metabolism and cognitive impairment. However, the precise nature and developmental trajectory of this cognitive impairment remains unclear. The present study used a verbal fluency task to dissociate executive and verbal processes in children with PKU (n = 23; 7–18 years) and controls (n = 44; 7–19 years). Data were collected at three longitudinal timepoints over a three-year period, and the contributions of age, group, and their interaction to fluency performance were evaluated. Results indicated impairments in executive processes in children with PKU, which were exacerbated by declining metabolic control. |
| Databáze: | OpenAIRE |
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