In vitro Activity of Sparfloxacin and Other Antimicrobial Agents against Genital Pathogens
| Autor: | J. C. Lefevre, E. Gaubert, R. Bauriaud, M. B. Lareng, M. C. Escaffre |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Chlamydia trachomatis
Microbial Sensitivity Tests Mycoplasma hominis Quinolones Biology medicine.disease_cause Microbiology Mycoplasma Anti-Infective Agents Species Specificity Drug Discovery medicine heterocyclic compounds Pharmacology (medical) Antibacterial agent Pharmacology Bacteria Temafloxacin General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Antimicrobial Gardnerella vaginalis Virology Neisseria gonorrhoeae female genital diseases and pregnancy complications Anti-Bacterial Agents Infectious Diseases Sparfloxacin Oncology bacteria Ampicillin Ureaplasma urealyticum Fluoroquinolones medicine.drug |
| Zdroj: | Chemotherapy. 38:303-307 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000239018 |
| Popis: | The in vitro activity of sparfloxacin was determined for 60 strains of Neisseria gonorrhoeae, 15 strains of Chlamydia trachomatis and 40 strains each of Gardnerella vaginalis, Mycoplasma hominis, and Ureaplasma urealyticum and compared with those of ampicillin, azithromycin, clarithromycin, erythromycin, ofloxacin, temafloxacin and tetracycline. Sparfloxacin was active against all the strains studied and appeared to be the most potent quinolone tested. Sparfloxacin had the lowest MICs against N. gonorrhoeae (MICs 0.002-0.06 micrograms/ml). Its MICs against C. trachomatis (0.03-0.06 micrograms/ml) were higher than those of clarithromycin but lower than those of the other antimicrobial agents. Sparfloxacin was particularly active against tetracycline-susceptible as well as resistant strains of M. hominis (MICs, 0.06 micrograms/ml) and U. urealyticum (MICs 0.125-1 micrograms/ml). Because of this in vitro activity and its tissue distribution, sparfloxacin might be a valuable therapeutic agent for treating major bacterial sexually transmitted diseases. |
| Databáze: | OpenAIRE |
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