Current concepts in tissue engineering technique for repair of cartilage defect
| Autor: | Yuji Uchio, Mitsuo Ochi, Masatoshi Tobita, Masakazu Kuriwaka |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Cartilage Articular Male Adolescent Knee Joint Biomedical Engineering Medicine (miscellaneous) Bioengineering Articular cartilage Biocompatible Materials Chondrocyte phenotype Chondrocyte Biomaterials Chondrocytes Tissue engineering Articular cartilage repair Medicine Animals Humans Cells Cultured Aged Bioartificial Organs business.industry Cartilage General Medicine Prostheses and Implants Middle Aged Chondrogenesis Transplantation medicine.anatomical_structure Female Collagen Rabbits business Biomedical engineering |
| Zdroj: | Artificial organs. 25(3) |
| ISSN: | 0160-564X |
| Popis: | Hunter's observation in 1743 that cartilage "once destroyed, is not repaired," has not essentially changed for 250 years. At present, there is no well-established procedure for the repair of cartilage defect with articular cartilage, which has the same biochemical and biomechanical properties as the surrounding normal intact cartilage. In 1994, transplantation of human autologous chondrocytes in suspension, as reported by Brittberg et al., provided a potential procedure for articular cartilage repair. We have improved their procedure and developed a new technique which creates new cartilage-like tissue by cultivating autologous chondrocytes embedded in Atelocollagen gel for 3 weeks before transplantation. These improvements maintained the chondrocyte phenotype, evenly distributed chondrocytes throughout the osteochondral defects, and decreased the risk of leakage of grafted chondrocytes into the defects. Good clinical results suggest that this technique should be a promising procedure for repairing articular cartilage defect. |
| Databáze: | OpenAIRE |
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