The Paradox of Muscle Hypertrophy in Muscular Dystrophy
| Autor: | Jiahui Wang, Kathryn R. Wagner, Joe N. Kornegay, Scott J. Schatzberg, Zheng Fan, Peter P. Nghiem, Martin K. Childers, Martin Styner, Daniel J. Bogan, James F. Howard, Janet R. Bogan, Robert W. Grange, Eric P. Hoffman, Jennifer L. Dow |
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| Rok vydání: | 2012 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Contracture Connective tissue Physical Therapy Sports Therapy and Rehabilitation Myostatin Article Muscular Dystrophies Muscle hypertrophy Dystrophin Atrophy Internal medicine medicine Animals Humans Kyphosis Muscle Strength Muscular dystrophy Muscle Skeletal biology business.industry Rehabilitation Hypertrophy medicine.disease Muscle atrophy Disease Models Animal Endocrinology medicine.anatomical_structure biology.protein medicine.symptom business |
| Zdroj: | Physical Medicine and Rehabilitation Clinics of North America. 23:149-172 |
| ISSN: | 1047-9651 |
| Popis: | Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans and syndromes in mice, dogs, and cats. Affected humans and dogs have progressive disease that leads primarily to muscle atrophy. Mdx mice progress through an initial phase of muscle hypertrophy followed by atrophy. Cats have persistent muscle hypertrophy. Hypertrophy in humans has been attributed to deposition of fat and connective tissue (pseudohypertrophy). Increased muscle mass (true hypertrophy) has been documented in animal models. Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy. |
| Databáze: | OpenAIRE |
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