Anopheline bionomics, insecticide resistance and transnational dispersion in the context of controlling a possible recurrence of malaria transmission in Jaffna city in northern Sri Lanka

Autor: Annathurai Tharsan, Sharanga Santhirasegaram, Selvarajah Raveendran, Vaikunthavasan Thiruchenthooran, Sinnathamby N. Surendran, Ranjan Ramasamy, Kokila Sivabalakrishnan, Tibutius T. P. Jayadas
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Veterinary medicine
Insecticides
Tamil Nadu
chemistry.chemical_compound
0302 clinical medicine
Recurrence
Pyrethrins
Anopheles culicifacies
Mosquito range expansion
biology
Ecology
Infectious Diseases
Anopheles malaria vectors
Larva
Jaffna
Malathion
Sequence Analysis
Anopheles subpictus
Insecticide resistance
Malaria control
030231 tropical medicine
India
Context (language use)
Mosquito Vectors
Transnational mosquito migration
lcsh:Infectious and parasitic diseases
DDT
03 medical and health sciences
Bionomics
parasitic diseases
Anopheles
Nitriles
medicine
Animals
lcsh:RC109-216
Anopheles stephensi
Sri Lanka
Research
fungi
Larval habitats
Sequence Analysis
DNA
medicine.disease
biology.organism_classification
Malaria
030104 developmental biology
Deltamethrin
chemistry
Parasitology
kdr mutation
Zdroj: Parasites & Vectors
Parasites & Vectors, Vol 13, Iss 1, Pp 1-9 (2020)
ISSN: 1756-3305
Popis: Background Malaria was eliminated from Sri Lanka in 2013. However, the influx of infected travelers and the presence of potent anopheline vectors can re-initiate transmission in Jaffna city, which is separated by a narrow strait from the malaria-endemic Indian state of Tamil Nadu. Methods Anopheline larvae were collected from different habitats in Jaffna city and the susceptibility of emergent adults to DDT, malathion and deltamethrin investigated. Results Anopheline larvae were found in wells, surface-exposed drains, ponds, water puddles and water storage tanks, with many containing polluted, alkaline and brackish water. Anopheles culicifacies, An. subpictus, An. stephensi and An. varuna were identified in the collections. Adults of the four anopheline species were resistant to DDT. Anopheles subpictus and An. stephensi were resistant while An. culicifacies and An. varuna were possibly resistant to deltamethrin. Anopheles stephensi was resistant, An. subpictus possibly resistant while An. varuna and An. culicifacies were susceptible to malathion. DNA sequencing showed a L1014F (TTA to TTC) mutation in the IIS6 transmembrane segment of the voltage-gated sodium channel protein in deltamethrin-resistant An. subpictus—a mutation previously observed in India but not Sri Lanka. Conclusion Anopheles subpictus in Jaffna, like An. stephensi, may have recently originated in coastal Tamil Nadu. Besides infected overseas travelers, wind- and boat-borne carriage of Plasmodium-infected anophelines across the Palk Strait can potentially reintroduce malaria transmission to Jaffna city. Adaptation to diverse larval habitats and resistance to common insecticides in anophelines are identified as potential problems for vector control should this happen.
Databáze: OpenAIRE
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