A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review)
| Autor: | Michal Nohawica, Abdelmounaim Errachid, Marzena Wyganowska‑Swiatkowska |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Saliva
Salivary gland Tight junction Chemistry salivary glands General Neuroscience Mucin food and beverages Review General Medicine Epigallocatechin gallate Secretory Vesicle General Biochemistry Genetics and Molecular Biology Exocytosis Cell biology aquaporin chemistry.chemical_compound medicine.anatomical_structure soluble N-ethylmaleimide-sensitive factor attachment protein receptors medicine Sjögren's syndrome Secretion General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Biomedical Reports |
| ISSN: | 2049-9442 2049-9434 |
| Popis: | Sjögren's syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to reduced secretory functions and oral and ocular dryness. The salivary glands are composed of acinar cells that are responsible for the secretion and production of secretory granules, which contain salivary components, such as amylase, mucins and immunoglobulins. This secretion process involves secretory vesicle trafficking, docking, priming and membrane fusion. A failure during any of the steps in exocytosis in the salivary glands results in the altered secretion of saliva. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors, actin, tight junctions and aquaporin 5 all serve an important role in the trafficking regulation of secretory vesicles in the secretion of saliva via exocytosis. Alterations in the expression and distribution of these selected proteins leads to salivary gland dysfunction, including SS. Several studies have demonstrated that green tea polyphenols, most notably Epigallocatechin gallate (EGCG), possess both anti-inflammatory and anti-apoptotic properties in normal human cells. Molecular, cellular and animal studies have indicated that EGCG can provide protective effects against autoimmune and inflammatory reactions in salivary glands in diseases such as SS. The aim of the present article is to provide a comprehensive and up-to-date review on the possible therapeutic interactions between EGCG and the selected molecular mechanisms associated with SS. |
| Databáze: | OpenAIRE |
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