Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?
| Autor: | Jeannette Boerop, Michaela Diamant, Cees Rustemeijer, Jan H. Verheijen, Roeland Hanemaaijer, Maarten E. Tushuizen, Henk J. G. Bilo, Nynke J. van der Zijl, Roger K. Schindhelm |
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| Přispěvatelé: | Internal medicine, Gastroenterology and hepatology, ICaR - Ischemia and repair |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Urinary system Clinical Biochemistry Renal function Diabetic nephropathy Internal medicine Diabetes mellitus Type 2 diabetes mellitus medicine Albuminuria Humans Diabetic Nephropathies Aged MMP-2 business.industry Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease Pathophysiology Matrix Metalloproteinase 8 Blood pressure Endocrinology Diabetes Mellitus Type 2 Matrix Metalloproteinase 9 Multivariate Analysis Female medicine.symptom MMP-9 business MMP-8 |
| Zdroj: | Clinical Biochemistry Clinical Biochemistry, 43(7-8), 635-639. Elsevier Inc. Clinical Biochemistry, 43(7-8), 635-639. PERGAMON-ELSEVIER SCIENCE LTD van der Zijl, N J, Hanemaaijer, L, Tushuizen, M E, Schindhelm, R K, Boerop, J, Rustemeijer, C, Bilo, H J, Verheijen, J H & Diamant, M 2010, ' Urinary matrix metalloproteinase-8 and-9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy? ', Clinical Biochemistry, vol. 43, no. 7-8, pp. 635-639 . https://doi.org/10.1016/j.clinbiochem.2010.02.006 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2010.02.006 |
| Popis: | Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors for ON in T2DM patients with (UA, n=27) and without albuminuria (NA, n=48) and controls (CO, n=28). MMP-8 and -9 levels were highest in UA patients (P |
| Databáze: | OpenAIRE |
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