Immunomodulating activities associated with the cytosol fraction of a 3-methylcholanthrene-induced rat fibrosarcoma—II. Association with polyamine complexes
| Autor: | Raymond C. Depieds, M.M. Remacle-Bonnet, F L Garrouste, Gilbert Pommier |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Fibrosarcoma
Spermine Biology Lymphocyte Activation Guanidines Biochemistry chemistry.chemical_compound Cytosol Immune Tolerance Polyamines medicine Animals Oxidoreductases Acting on CH-NH Group Donors Fetus medicine.disease Molecular biology Neoplasm Proteins Rats Spermidine Kinetics chemistry Methylcholanthrene Cattle Polyamine Polyamine oxidase |
| Zdroj: | International Journal of Biochemistry. 18:557-564 |
| ISSN: | 0020-711X |
| DOI: | 10.1016/0020-711x(86)90168-0 |
| Popis: | 1. 1. This paper characterizes the molecular nature of the factors present in cytosol from F-344 rat McFiFi2(s) fibrosarcoma cells (FiCF) which mediate inhibition of PHA-induced lymphoproliferative responses. 2. 2. These are polyamines (spermine/spermidine) conjugated to different protein carriers. 3. 3. Interaction of these complexes with polyamine oxidase (PAO) present in fetal calf or rat serum is responsible of the suppression observed. |
| Databáze: | OpenAIRE |
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