Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking

Autor:	Anup M. Jawalekar, Annemieke Madder, Floris L. van Delft, Marieke Op de Beeck
Rok vydání:	2011
Předmět:	In situ Adenosine Stereochemistry Succinimides macromolecular substances Synthetic Organic Chemistry OXIDATION Ribosome Catalysis chemistry.chemical_compound LINKED DNA Furan DNA Interstrand Crosslinking Materials Chemistry medicine Moiety RIBOSOME Furans GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Bromosuccinimide Base Sequence DERIVATIVES Metals and Alloys technology industry and agriculture RNA MODIFIED OLIGONUCLEOTIDES DNA General Chemistry BASE Surfaces Coatings and Films Electronic Optical and Magnetic Materials Chemistry DUPLEXES Cross-Linking Reagents chemistry Ceramics and Composites Oxidation-Reduction medicine.drug
Zdroj:	Chemical Communications, 47, 2796-2798 Chemical Communications, 47, 10, pp. 2796-2798 CHEMICAL COMMUNICATIONS
ISSN:	1359-7345
Popis:	2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43d684604ab7f49602bd0aff1e6c68b http://hdl.handle.net/2066/92394 Zobrazit plný text záznamu