Serum paracetamol-protein adducts in ambulatory subjects: Relationship to recent reported paracetamol use
| Autor: | Richard C. Dart, Eric J. Lavonas, Kennon Heard, Victoria E. Anderson, Jody L. Green |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Analgesics.non-narcotic Protein adducts Health Toxicology and Mutagenesis Clinical Biochemistry Context (language use) Walking Pharmacology Drug overdose 030226 pharmacology & pharmacy Biochemistry Young Adult 03 medical and health sciences 0302 clinical medicine health services administration Humans Medicine Acetaminophen Dose-Response Relationship Drug business.industry organic chemicals digestive oral and skin physiology Blood Proteins Analgesics Non-Narcotic Middle Aged respiratory system medicine.disease Blood proteins Cross-Sectional Studies Potential biomarkers Ambulatory Female 030211 gastroenterology & hepatology Drug Overdose business medicine.drug |
| Zdroj: | Biomarkers. 23:288-292 |
| ISSN: | 1366-5804 1354-750X |
| DOI: | 10.1080/1354750x.2017.1410857 |
| Popis: | Serum paracetamol-protein adducts (PPAs) are a novel potential biomarker of paracetamol exposure. The relationship between serum PPA concentrations and reported paracetamol use in ambulatory adults has not been previously described.This was a cross-sectional study of ambulatory adults. A detailed medication history was obtained from all subjects and subjects were stratified by reported paracetamol use in the 2 weeks prior to enrolment. Serum PPAs were measured in all subjects and correlated with reported dose, time of last ingestion and demographics.We enrolled 230 in the paracetamol exposure arm and 74 in the no exposure arm. 98/230 (42.6%)of subjects who reported paracetamol exposure had PPA detected and 68/74 (91.9%) of subjects who denied paracetamol exposure had no PPA detected. PPA concentrations were positively correlated with total paracetamol dose and with more recent ingestion.Detection of serum PPA generally reflects paracetamol exposure histories in ambulatory adults. Concentrations are well correlated with reported dose and time from last dose.Serum PPA can be detected with reported therapeutic use of paracetamol but may not be detected in all patients who report taking paracetamol. |
| Databáze: | OpenAIRE |
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