COVID-2019 - A comprehensive pathology insight
| Autor: | Vishwas Luthra, Swarupa Ravuri, Narasimhamurthy Rajagopal, Chandrakumar Shanmugam, Abdul Rafi Mohammed, Saritha Karre |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
ARDS Pathology medicine.medical_specialty medicine.medical_treatment Pneumonia Viral SARS CoV-2 Article Pathology and Forensic Medicine Pathogenesis 03 medical and health sciences Betacoronavirus 0302 clinical medicine medicine Therapeutic targets Humans Respiratory system Pathological Pandemics Hyaline Mechanical ventilation business.industry SARS-CoV-2 COVID-19 Cell Biology medicine.disease Pneumonia 030104 developmental biology Respiratory failure 030220 oncology & carcinogenesis business Coronavirus Infections AFOP |
| Zdroj: | Pathology, Research and Practice |
| ISSN: | 1618-0631 |
| Popis: | Corona virus disease-2019 (COVID-19) caused by severe acute respiratory syndrome corona virus-2 (SARS CoV-2), a highly contagious single stranded RNA virus genetically related to SARS CoV. The lungs are the main organs affected leading to pneumonia and respiratory failure in severe cases that may need mechanical ventilation. Occasionally patient may present with gastro-intestinal, cardiac and neurologic symptoms with or without lung involvement. Pathologically, the lungs show either mild congestion and alveolar exudation or acute respiratory distress syndrome (ARDS) with hyaline membrane or histopathology of acute fibrinous organizing pneumonia (AFOP) that parallels disease severity. Other organs like liver and kidneys may be involved secondarily. Currently the treatment is principally symptomatic and prevention by proper use of personal protective equipment and other measures is crucial to limit the spread. In the midst of pandemic there is paucity of literature on pathological features including pathogenesis, hence in this review we provide the current pathology centered understanding of COVID-19. Furthermore, the pathogenetic pathway is pivotal in the development of therapeutic targets. |
| Databáze: | OpenAIRE |
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