Differences in kinetic metabolomics in Eisenia fetida under single and dual exposure of imidacloprid and dinotefuran at environmentally relevant concentrations
| Autor: | Xilong Wang, Shuangxi Li, Haiyun Zhang, Xianqing Zheng, Zhang Juanqin, Zhang Hanlin, Bai Naling, Yue Zhang, Julia Vidonish Aspinall, Weiguang Lv |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Eisenia fetida
Insecticides Environmental Engineering Health Toxicology and Mutagenesis 0211 other engineering and technologies Carnosine 02 engineering and technology 010501 environmental sciences 01 natural sciences Guanidines Dinotefuran chemistry.chemical_compound Neonicotinoids Soil Imidacloprid Environmental Chemistry Animals Metabolomics Soil Pollutants Oligochaeta Waste Management and Disposal Ecosystem 0105 earth and related environmental sciences chemistry.chemical_classification 021110 strategic defence & security studies biology Neonicotinoid Glutathione biology.organism_classification Nitro Compounds Pollution Amino acid chemistry Biochemistry Urea cycle |
| Zdroj: | Journal of hazardous materials. 417 |
| ISSN: | 1873-3336 |
| Popis: | Metabolomic responses of earthworms to neonicotinoids are important for understanding their molecular-level toxicity and assessing their ecological risks, but little is known until now. We investigated impact of imidacloprid (IMI, 52.6 ng/g) and dinotefuran (DIN, 52.5 ng/g) on Eisenia fetida metabolomics under single- and dual-compound exposure scenarios for one to four weeks. Dissimilar metabolites and anti-stress strategies were found for different neonicotinoids and exposure scenarios. Specifically, IMI exposure first increased myo-inositol and UDP-glucuronate associated with transmembrane absorption and transformation to IMI-urea, and then increased glutathione and fourteen amino acids (TCA cycle precursors) to resist stress and replenish energy. In contrast, worms exposed to DIN first prepared TCA cycle intermediates from glucosamine-6-phosphate and amino acids, suppressed urea cycle and DIN transformation, and then alleviated oxidative stress by increasing carnosine, nicotinate- D -ribonucleotide and nicotinamide-β-riboside. Dual exposure increased four eicosanoids by 1.6–1.9-fold, possibly associated with membrane lipid peroxidation; the amino acids consumed to balance the energy metabolism exhibited a wave-like pattern. This study first systematically revealed the compound/time/exposure scenario- dependent effects of trace neonicotinoids on earthworm metabolomics and advanced the understanding of their action modes. Neonicotinoid transformation was closely related to worms’ metabolic profiles, providing important insights in contaminant fate in soil ecosystems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect