MR spectroscopy of the brain in Leigh syndrome
| Autor: | Roelineke J. Lunsing, Lars A. Rodiger, van FrancJan Spronsen, Richard J. Rodenburg, Matthijs Oudkerk, Paul E. Sijens, Gerrit Smit |
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| Přispěvatelé: | University of Groningen, Faculteit Medische Wetenschappen/UMCG, Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Rok vydání: | 2008 |
| Předmět: |
Male
In vivo magnetic resonance spectroscopy Pathology medicine.medical_specialty Energy and redox metabolism [NCMLS 4] Kearns-Sayre Syndrome Brain tissue Choline Diagnosis Differential White matter Genomic disorders and inherited multi-system disorders [IGMD 3] chemistry.chemical_compound Developmental Neuroscience medicine Humans Brain magnetic resonance imaging Choline metabolism mitochondrial diseases business.industry Brain Infant General Medicine MAGNETIC-RESONANCE-SPECTROSCOPY Leigh syndrome magnetic resonance spectroscopy DEFICIENCY medicine.anatomical_structure Mitochondrial medicine [IGMD 8] chemistry Pediatrics Perinatology and Child Health Lactates Female Neurology (clinical) Leigh Disease business Cellular energy metabolism [UMCN 5.3] |
| Zdroj: | Brain & Development, 30, 9, pp. 579-83 Brain & Development, 30(9), 579-583. Elsevier Brain & Development, 30, 579-83 |
| ISSN: | 0387-7604 |
| Popis: | Contains fulltext : 69088.pdf (Publisher’s version ) (Closed access) Brain magnetic resonance spectroscopy in two patients with Leigh syndrome revealed the presence of lactate in gray and white matter brain tissue and relatively high choline levels in the white matter. The latter observation, most probably related to an ongoing demyelination process, underlines specific involvement of white matter metabolism in Leigh syndrome even in cases without involvement of the white matter as visualized on MRI. Magnetic resonance spectroscopy might thus be of help in differentiating Leigh syndrome from a range of other mitochondrial diseases, such as ophthalmoplegia and Kearns-Sayre syndrome, showing lack of lactate in brain tissues appearing normal on MRI. |
| Databáze: | OpenAIRE |
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