Lack of cross-sensitization between the locomotor-activating effects of bromocriptine and those of cocaine or heroin
| Autor: | Diane C. Hoffman, Roy A. Wise |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Quinpirole medicine.medical_treatment Pharmacology toxicology Environment Motor Activity Pharmacology Heroin Cocaine Dopamine Internal medicine medicine Animals Ergolines Bromocriptine Sensitization Receptors Dopamine D2 Rats Stimulant medicine.anatomical_structure Endocrinology Dopamine Agonists Home cage Cues Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 110:402-408 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | Rats were given daily injections of bromocriptine (5.0 mg/kg IP) or vehicle either in the home cage or in a test box equipped with photocells to measure locomotion. The animals were then tested in the photocell boxes for their locomotor response to cocaine (10.0 mg/kg IP), heroin (0.5 mg/kg IP), or quinpirole (0.1 mg/kg IP). Repeated bromocriptine in the test box but not in the home cage caused progressive increases in sensitivity to the locomotor-stimulating effects of bromocriptine and increases in the subsequent sensitivity to quinpirole but caused only trivial signs of cross-sensitization to cocaine or heroin. Cross-sensitization to quinpirole was temporary; responsiveness to quinpirole decreased with further quinpirole injections. Lack of significant cross-sensitization between bromocriptine and either cocaine or heroin and lack of permanence of the cross-sensitization between bromocriptine and quinpirole raise questions as to the biological basis of psychomotor stimulant sensitization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink