Association Between Genetic Polymorphism of XRCC1 Gene and Risk of Glioma in а Chinese Population
| Autor: | Ding-Bo Tao, Xiang Dong, Kai Fan, Ying-Xin Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male China Cancer Research Candidate gene Genotype Epidemiology Biology Polymerase Chain Reaction XRCC1 Asian People Risk Factors Glioma Biomarkers Tumor medicine Humans Genetic Predisposition to Disease Allele Genetic association Polymorphism Genetic Brain Neoplasms Public Health Environmental and Occupational Health Case-control study Odds ratio Middle Aged Prognosis medicine.disease DNA-Binding Proteins X-ray Repair Cross Complementing Protein 1 Oncology Case-Control Studies Cancer research Female Polymorphism Restriction Fragment Length Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:5957-5960 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2013.14.10.5957 |
| Popis: | Background: Gliomas are the most common type of primary brain tumor in adults, and the X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene influencing its risk. The objective of this study was to detect the influence of XRCC1 genetic polymorphisms on glioma risk. Materials and Methods: A total of 629 glioma patients and 641 cancer-free subjects were enrolled in this case-control study. The genotypes of the c.1471G>A genetic polymorphism were determined by created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods. The influence of the XRCC1 genetic polymorphism on glioma risk was evaluated by association analysis. Results: Our data indicated that the alleles/genotype of this genetic variant was statistically associated with glioma risk. The AA genotype was statistically associated with the increased risk of glioma compared to the GG wild genotype (odds ratios (OR) = 1.89, 95% CI 1.25-2.87, P = 0.003). The allele-A may contribute to increased the susceptibility to glioma (OR = 1.23, 95% CI 1.04-1.46, P = 0.017). Conclusions: These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential to influence glioma susceptibility, and might be used as molecular marker for assessing glioma risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|