Longer survival of rat limb allograft: Combined immunosuppression of FK-506 and 15-deoxyspergualin
| Autor: | Shinya Kawai, Kazuteru Doi, Mitsunori Shigetomi, Tatsuaki Akino, Keiichi Muramatsu |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Guanidines Tacrolimus medicine Animals Transplantation Homologous Orthopedics and Sports Medicine Immunosuppressive effect Chemotherapy business.industry Graft Survival Drug Synergism Rats Inbred Strains Immunosuppression Right hindlimb Hindlimb Rats Surgery Transplantation Rats Inbred Lew Anesthesia Cyclosporine Graft survival business Immunosuppressive Agents Allotransplantation |
| Zdroj: | Acta Orthopaedica Scandinavica. 68:581-585 |
| ISSN: | 0001-6470 |
| DOI: | 10.3109/17453679708999031 |
| Popis: | We studied the individual and synergistic effect of 3 immunosuppressive drugs, FK-506 (1 mg/kg/day), 15-deoxyspergualin (2.5 mg/kg/day) and cyclosporine (15 mg/kg/day) in a DA/Lewis rat limb allotransplantation model. 74 right hindlimb transplantations were performed. The median time for onset of rejection was 4 days in animals without immunosuppression, 37 days in animals receiving cyclosporine immunosuppression for 30 days, 61 days in animals receiving FK-506 for 30 days, 36 days in animals receiving a 30-day course of cyclosporine and, in the first 15 days, a course of 15-deoxyspergualin, and 76 days in animals receiving a 30-day course of FK-506 and 15-deoxyspergualin in the first 15 days. The combination of cyclosporine with 15-deoxyspergualin did not prolong graft survival and no synergistic effect was evident. In contrast, survival time in rat limb allografts receiving FK-506 and 15-deoxyspergualin was longer than in those receiving single FK-506 therapy. Our findings suggest a positive synergistic immunosuppressive effect with FK-506 and 15-deoxyspergualin in limb allotransplantation. |
| Databáze: | OpenAIRE |
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