Comparisons of the efficacy of 186Re- and 131I-labeled antibody in multicell spheroids
| Autor: | Fu-min Su, Virginia K. Langmuir, Holly L. Mendonca, J.-L. Vanderheyden |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
medicine.medical_treatment Radiation Dosage Iodine Radioisotopes Beta particle medicine Tumor Cells Cultured Dosimetry Humans Radiology Nuclear Medicine and imaging Clonogenic assay Radioisotopes Radiation biology business.industry Spheroid Penetration (firestop) Radioimmunotherapy medicine.disease Rhenium Oncology biology.protein Adenocarcinoma Autoradiography Antibody Nuclear medicine business |
| Zdroj: | International journal of radiation oncology, biology, physics. 24(1) |
| ISSN: | 0360-3016 |
| Popis: | Several radionuclides are being studied for use in radioimmunotherapy. Although 131I has been used most widely, there are several disadvantages to it including its large gamma-ray component, its rather long half-life, and its modest beta-particle energy. However, the beta-particle energy can be an advantage in very small tumors (less than 1-2 mm). 186Re has several potential advantages over 131I but it has never been directly compared with it experimentally. Dosimetry modeling predicted that 186Re would have a dose advantage over 131I at large tumor sizes but for tumors as small as 1 mm diameter, this advantage would be lost. In order to confirm these predictions experimentally, this study compared the relative efficacy of a pancarcinoma antibody, NR-LU-10 labeled with 186Re or 131I in 0.8-1.0 mm diameter LS174T human colon adenocarcinoma multicell spheroids. Spheroids were incubated for 90 hr at 37 degrees C and evaluated with clonogenic assay, autoradiography, and histology. When corrected for cumulative activity bound, both radionuclides were equally effective. Autoradiography demonstrated poor penetration of radionuclide into the depths of the spheroids. Because 186Re has a theoretical dose advantage in larger tumors and because it has been shown to be equivalent to 131I in tumors as small as 1 mm diameter, it may be superior to 131I in most clinical situations. However, in the treatment of micrometastases of less than 1 mm diameter, theoretical dosimetry modeling predicts that 131I or radionuclides with similar beta particle energies should be more effective. |
| Databáze: | OpenAIRE |
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